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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Combination therapy of canine osteosarcoma with canine bone marrow stem cells, bone morphogenetic protein and carboplatin in an in vivo model

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Author(s):
Rici, R. E. G. [1] ; Will, S. E. A. L. [2] ; Luna, A. C. L. [2] ; Melo, L. F. [1] ; Santos, A. C. [1] ; Rodrigues, R. F. [1] ; Leandro, R. M. [1] ; Maria, D. A. [2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
[2] Butantan Inst, Lab Biochem & Biophys, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: VETERINARY AND COMPARATIVE ONCOLOGY; v. 16, n. 4, p. 478-488, DEC 2018.
Web of Science Citations: 1
Abstract

Osteosarcoma (OSA) is the most common malignant bone cancer in children and dogs. The therapeutic protocols adopted for dogs and humans are very similar, involving surgical options such as amputation. Besides surgical options, radiotherapy and chemotherapy also are adopted. However, hematologic, gastrointestinal and renal toxicity may occur because of chemotherapy treatments. Recent study clearly showed that mesenchymal stem cells (MSCs) combined with recombinant human bone morphogenetic protein (rhBMP-2) may be associated with decreases of the tumorigenic potential of canine OSA. The aim of this study was to analyse the efficacy of chemotherapy with carboplatin and rhBMP-2 with MSCs in a canine OSA in vivo model. Canine OSA cells were implanted in mice Balb-c/nude with MSCs, rhBMP-2 and carboplatin. Flow cytometry and PCR for markers involved in tumour suppression pathways were analysed. Results showed that the combination of MSCs and rhBMP-2 reduced tumour mass and infiltration of neoplastic cells in tissues more efficiently than carboplatin alone. Thus it was demonstrated that the use of rhBMP-2 and MSCs, in combination with conventional antineoplastic, may be an efficient treatment strategy. (AU)

FAPESP's process: 12/21191-6 - Mesenchymal stem cells (MSCs) and morphogenetic protein (rhBMP-2) associated to chemotherapy: a new perspective for a canine osteosarcoma therapy
Grantee:Rose Eli Grassi Rici
Support Opportunities: Regular Research Grants