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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia

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Author(s):
Mendes-dos-Santos, Carolina Taddeo [1] ; Martins, Daniel Lahan [2] ; Guerra-Junior, Gil [1] ; Matias Baptista, Maria Tereza [1] ; de-Mello, Maricilda Palandi [3] ; de Oliveira, Laurione Candido [4] ; Morcillo, Andre Moreno [1] ; Valente Lemos-Marini, Sofia Helena [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Dept Pediat, Pediat Endocrinol Unit, CIPED, Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Dept Radiol, Campinas, SP - Brazil
[3] Univ Estadual Campinas, UNICAMP, Ctr Mol Biol & Genet Engn CBMEG, Campinas, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Clin Hosp, Lab Physiol, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Hormone Research in Paediatrics; v. 90, n. 3, p. 161-168, 2018.
Web of Science Citations: 3
Abstract

Background: Testicular adrenal rest tumors (TART) can cause infertility in congenital adrenal hyperplasia (CAH) males. Aims: To determine TART prevalence in patients with CAH due to 21-hydroxylase deficiency (21-OHD) and evaluate possible factors associated with its development. Methods: This is a descriptive and analytical cross-sectional study evaluating males with the classical form of 21-OHD through testicular ultrasonography and serum inhibin B dosages. Data on prescribed glucocorticoid dose and serum levels of 17 hydroxyprogesterone (17-OHP), androstenedione (Andro), ACTH, renin, and LH were obtained from medical records. Results: Thirty-eight males were evaluated. The mean age on ultrasonography was 15.2 +/- 6.7 (3-27) years. Nine patients (23.7%) had TART, 4 of them were prepubertal and the youngest was 5 years old. No association was found between TART and 21-OHD phenotype, glucocorticoid dose, or 17OHP, ACTH, LH, renin, and inhibin B levels measured in the 6 preceding years. However, 50% of the patients who presented increased Andro 2 years prior to the evaluation had TART (p = 0.018, OR = 8.00 {[}95% CI: 1.42-44.92]), whereas in the normal Andro group only 16.7% had tumors. Conclusion: This study showed that TART can occur in prepubertal patients and that disease control could be a factor associated with its development. Therefore, we suggest investigating TART development early in childhood, mainly in poorly controlled 21-OHD patients. (c) 2018 S. Karger AG, Basel (AU)