Neck circumference is associated with non-traditional cardiovascular risk factors in individuals at low-to-moderate cardiovascular risk: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Author(s):Show less -

Almeida-Pititto, B. ^[1] ; Silva, I. T. ^[2] ; Goulart, A. C. ^{[3, 4]} ; Fonseca, M. I. H. ^[2] ; Bittencourt, M. S. ^[4] ; Santos, R. D. ^[5] ; Blaha, M. ^[6] ; Jones, S. ^[6] ; Toth, P. P. ^{[6, 7]} ; Kulakarni, K. ^[8] ; Lotufo, P. A. ^[3] ; Bensenor, I. M. ^[3] ; Ferreira, S. R. G. ^{[2, 3]} ; Grp, ELSA Res

Affiliation

^[1] Univ Fed Sao Paulo, Dept Prevent Med, Rua Botucatu 740, BR-04023900 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Publ Hlth, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Univ Hosp, Ctr Clin & Epidemiol Res, Av Lineu Prestes 2565, 3rd Floor, BR-05508000 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Internal Med, Av Lineu Prestes 2565, 4th Floor, BR-05508000 Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Med Sch Hosp, Lipid Clin Heart Inst InCor, Av Dr Eneas de Carvalho Aguiar 44, BR-01246000 Sao Paulo - Brazil

^[6] Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Blalock 524 D1, 600 N Wolfe St, Baltimore, MD - USA

^[7] CGH Med Ctr, Dept Prevent Cardiol, 100 E Le Fevre Rd, Sterling, IL 61081 - USA

^[8] VAP Diagnost Lab, 201 London Pkwy, Birmingham, AL 35211 - USA

• Document type: Journal article
• Source: DIABETOLOGY & METABOLIC SYNDROME; v. 10, NOV 20 2018.
• Web of Science Citations: 0

Abstract

Background: Neck circumference (NC) is associated with traditional cardiovascular risk factors (CVRF), but its usefulness to identify earlier atherogenic risk has been scarcely examined. Associations of NC with non-traditional CVRF were investigated in participants at low-to-moderate risk from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: 807 individuals (35-54 years) without obesity, diabetes or cardiovascular disease was stratified into quartiles of NC (cut-off for men: 36.5; 37.9 and 39.5 cm; women: 31.4; 32.5 and 34 cm) and traditional and non-traditional risk factors (lipoprotein subfractions by Vertical Auto Profile, adiponectin, leptin, E-selectin) were compared across groups. In linear regression models, associations of NC with non-traditional risk factors were tested for the entire sample and for low-risk group (<= 2 CVRF). Results: In both sexes, BMI, waist circumference, systolic and diastolic blood pressure, fasting and 2-h plasma glucose, HOMA-IR, triglycerides, leptin, E-selectin, small dense LDL-cholesterol, IDL-cholesterol, VLDL3-cholesterol and TG/HDL ratio increased significantly, while HDL2-cholesterol and HDL3-cholesterol decreased across NC quartiles. In linear regression models, a direct association {[}beta(95% CI)] of NC with leptin {[}(0.155 (0.068-0.242); 0.147 (0.075-0.220)], E-selectin {[}(0.105 (0.032-0.177); 0.073 (0.006 to 0.140)] and small-dense LDL {[}(1.866 (0.641-3.091); 2.372 (1.391-3.353)] and an inverse association with HDL2-cholesterol {[}(-0.519 (-0.773 to -0.266); -0.815 (-1.115 to 0.515)] adjusted for age were detected for men and women, respectively. Conclusion: Our findings indicate that measurement of NC may be useful for an earlier identification of unfavorable atherogenic metabolic profile in middle-aged individuals at lower cardiovascular risk level. (AU)

• FAPESP's process: 10/00074-6 - Non-traditional cardiometabolic risk factors on the spectrum of metabolic syndrome in ELSA - São Paulo
• Grantee: Bianca de Almeida Pititto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral