Candida auris: What Have We Learned About Its Mechanisms of Pathogenicity?

Author(s)

Rossato, Luana ^[1] ; Colombo, Arnaldo Lopes ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Special Mycol Lab, Sao Paulo - Brazil

• Document type: Review article
• Source: FRONTIERS IN MICROBIOLOGY; v. 9, DEC 12 2018.
• Web of Science Citations: 6

Abstract

Candida auris has emerged globally as a multidrug-resistant (MDR) medical care-associated fungal pathogen. Recent reports have demonstrated that C. auris usually expresses fewer virulence factors than does Candida albicans. However, the tendency of C. auris transmission within and between healthcare facilities is unique among Candida spp. and is possibly promoted by virulence and pathogenicity factors that facilitate skin colonization and environmental persistence. To understand the ability of this yeast to cause disease, we herein discuss several virulence and pathogenicity aspects of C. auris. (AU)

• FAPESP's process: 17/19095-2 - Investigation of the virulence and immune response against Candida auris using alternative model Caenorhabditis elegans
• Grantee: Luana Rossato
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/02203-7 - Multidisciplinary and international network to characterize microbiological aspects and natural history of invasive fungal infections due Candida spp
• Grantee: Arnaldo Lopes Colombo
• Support Opportunities: Research Projects - Thematic Grants