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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bleeding during and after dental extractions in patients with liver cirrhosis

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Author(s):
Medina, J. B. [1, 2] ; Andrade, N. S. [1] ; de Paula Eduardo, F. [3] ; Bezinelli, L. [3] ; Franco, J. B. [4] ; Gallottini, M. [1] ; Braz-Silva, P. H. [1, 5] ; Ortega, K. L. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Dept Stomatol, Sch Dent, Sao Paulo - Brazil
[2] Mario Covas State Hosp Santo Andre, Div Dent, Sao Paulo - Brazil
[3] Albert Einstein Hosp, Sao Paulo - Brazil
[4] Univ Sao Paulo, Med Sch, Hosp Clin, Div Dent, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Trop Med Sao Paulo, Lab Virol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: International Journal of Oral and Maxillofacial Surgery; v. 47, n. 12, p. 1543-1549, DEC 2018.
Web of Science Citations: 2
Abstract

Little is known about the prevention and management of acquired coagulopathies, such as those affecting cirrhotic patients. The objective of this analytic retrospective observational study was to evaluate patients on the liver transplant waiting list according to the following outcomes: (1) presence of unusual intraoperative bleeding (>10 min after routine haemostatic procedures); and (2) presence of postoperative haemorrhagic complications. The outcomes were analysed according to clinical and laboratory variables. A total of 190 visits were performed for extraction of 333 teeth (ranging from 1 to 9 teeth per visit), with platelet count ranging from 16,000 to 216,000 and international normalized ratio (INR) below 3. Twelve cases (6.31%) had unusual intraoperative bleeding and 12 had postoperative haemorrhagic complications. All the events were controlled by local measures. Intraoperative bleeding was associated with low count of platelets (P = 0.026). However, this counting could explain only 16% (adjusted R-2 = 0.16) of the cases of bleeding (P = 0.44), meaning that platelet function changes might be involved. Our results show that cirrhotic patients presenting platelet count above 16,000 and INR below 3 need no previous blood transfusion, with local measures being enough to manage haemorrhagic events. (AU)

FAPESP's process: 15/07727-9 - Evaluation of immunoregulatory microenvironment of oral premalignant lesions, squamous cell carcinomas and oropharyngeal carcinomas related to HPV or not.
Grantee:Paulo Henrique Braz da Silva
Support Opportunities: Regular Research Grants