Synthesis of amidoglucals and glucal esters via carbonylative coupling reactions of 2-iodoglucal using Mo(CO)(6) as a CO source

Author(s)

Darbem, Mariana P. ^[1] ; Kanno, Karina S. ^[1] ; de Oliveira, Isadora M. ^[2] ; Esteves, C. Henrique A. ^[1] ; Pimenta, Daniel C. ^[3] ; Stefani, Helio A. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim, Sao Paulo, SP - Brazil

^[3] Inst Butantan, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: NEW JOURNAL OF CHEMISTRY; v. 43, n. 2, p. 696-699, JAN 14 2019.
• Web of Science Citations: 6

Abstract

The synthesis of amidoglucals and glucal esters in good to high yields using 2-iodo-3,4,6-tri-O-acetyl-d-glucal as a substrate, Mo(CO)(6) as a carbon monoxide source and PdCl2 as a catalyst is reported. This procedure shows advantages when compared to other published methodologies, as it is carried out in one pot relying on short reaction times at mild temperatures, under ligand-free conditions and with only one equivalent of Mo(CO)(6). (AU)

• FAPESP's process: 17/26673-2 - CuH-Catalyzed fluorination of alkenes and PET applications
• Grantee: Carlos Henrique Alves Esteves
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/24821-4 - Carbonylative Coupling and Intramolecular Cycloaddition [2 + 2] Reactions Employing D-Glucal
• Grantee: Helio Alexandre Stefani
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/04289-3 - Synthesis of calcogeno amino acids derivatives and 4-calcogeno quinolines via multicomponent reactions
• Grantee: Isadora Maria de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 16/24396-9 - Triazolic 2-Aryloxazolines: synthesis of small libraries, biological activity, fluorescence and ligands
• Grantee: Mariana Pompilio Darbem Rocha
• Support Opportunities: Scholarships in Brazil - Doctorate