| Full text | |
| Author(s): Show less - |
Lania, Bruno Grosselli
[1]
;
Morari, Joseane
[2, 3]
;
de Almeida, Amanda Roberta
[1]
;
da Silva, Marilene Neves
[1]
;
Vieira-Damiani, Gislaine
[1]
;
Lins, Karina de Almeida
[1]
;
Cesar, Carlos Lenz
[4]
;
Velloso, Licio Augusto
[5, 2, 3]
;
Maia, Nilson Borlina
[6]
;
Cintra, Maria Leticia
[7]
;
Neves Ferreira Velho, Paulo Eduardo
[5, 1]
Total Authors: 11
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Med Sci, Lab Appl Res Dermatol & Bartonella Infect, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Cell Signaling Lab, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Obes & Comorbid Res Ctr, Campinas, SP - Brazil
[4] Univ Estadual Campinas, Gleb Wataghin Inst Phys, Natl Inst Photon Appl Cell Biol INFABIC, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Sch Med Sci, Dept Clin Med, Campinas, SP - Brazil
[6] Univ Estadual Campinas, Agron Inst Campinas, Aromat Plants Div, Campinas, SP - Brazil
[7] Univ Estadual Campinas, Dept Pathol Anat, Sch Med Sci, Campinas, SP - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | PLoS One; v. 14, n. 1 JAN 4 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Background The use of medicinal plants and their derivatives is increasing, and approximately one-third of all traditional herbal medicines are intended for wound treatment. Natural products used in these treatments include vegetable oils, which are rich in essential fatty acids. Once in contact with an ulcerative surface, the oil reaches the blood and lymphatic vessels, thus eliciting systemic effects. Objective This study evaluated the local and possible systemic effects of essential fatty acids (sunflower oil) applied topically to rat wounds. Methods Cutaneous punch wounds (6 mm) were produced on the dorsa of 30 rats. Saline (SS), mineral oil (MO) or essential fatty acid (EFA) solutions were applied topically. Healing was evaluated after 2, 4 and 10 days (n = 5 per group) by visual and histological/morphometric examination, second harmonic generation (SHG) microscopy, and cytokine and growth factor quantification in the scar tissue (real-time PCR) and in serum (ELISA). Results MO/EFA-treated animals had higher IGF-1, leptin, IL-6 and IFN-gamma mRNA expression and lower serum IL-6 levels than the control (SS/MO) animals. SHG analysis showed no difference in collagen density between the animals treated with MO and EFA. Conclusion EFA treatment induces topical (observed by local IGF-1, leptin, IL-6 and IFN-gamma production) and systemic effects, lowering IL-6 levels in the serum. As the oil is widely used to shorten ulcer healing time, studies are needed to evaluate the treatment safety and possible undesired effects. (AU) | |