| Full text | |
| Author(s): |
Annelyze Podolan Kloster
[1]
;
Natalino Lourenço Neto
[2]
;
Silgia Aparecida da Costa
[3]
;
Thais Marchini Oliveira
[4]
;
Rodrigo Cardoso de Oliveira
[5]
;
Maria Aparecida Andrade Moreira Machado
[6]
Total Authors: 6
|
| Affiliation: | [1] Universidade de São Paulo. Bauru Dental School. Department of Pediatric Dentistry, Orthodontics and Community Dentistry - Brasil
[2] Universidade de São Paulo. Bauru Dental School. Department of Pediatric Dentistry, Orthodontics and Community Dentistry - Brasil
[3] Universidade de São Paulo. School of Arts, Sciences and Humanities. Course on Textiles and Fashion - Brasil
[4] Universidade de São Paulo. Bauru Dental School. Department of Pediatric Dentistry, Orthodontics and Community Dentistry - Brasil
[5] Universidade de São Paulo. Bauru Dental School. Department of Biological Sciences, Discipline of Biochemistry - Brasil
[6] Universidade de São Paulo. Bauru Dental School. Department of Pediatric Dentistry, Orthodontics and Community Dentistry - Brasil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Brazilian Dental Journal; v. 29, n. 4, p. 354-358, 2018-08-00. |
| Abstract | |
Abstract This study aimed to evaluate in vitro the antimicrobial effect of a bioadhesive chitosan-based oral membrane with chlorhexidine for local treatment of infections in the oral tissues. Five oral membranes of different compositions were tested: 5% chitosan (G1); 5% chitosan ± 0.2% chlorhexidine (G2), 5% chitosan ± 0.6% chlorhexidine (G3), 5% chitosan ± 1.0% chlorhexidine (G4), and 5% chitosan ± 2.0% chlorhexidine (G5). Also, five gel types were tested according to the following compositions: 5% chitosan gel (G6), 0.2% chlorhexidine gel (G7), 2.0% chlorhexidine gel (G8), 5% chitosan gel ± 0.2% chlorhexidine gel (G9), and 5% chitosan gel ± 2.0% chlorhexidine gel (G10). The antimicrobial action of the samples was tested against Candida albicans and Streptococcus mutans through antibiogram by measuring the inhibition halos. Data were statistically analyzed by Kruskal-Wallis and one-way ANOVA followed by Tukey test (p<0.05). The 2.0% chlorhexidine membrane (G5) and the disks containing 2.0% chlorhexidine gel (G8) showed the greatest inhibition halos for both microorganisms, with statistically significant difference when compared to others tested groups (p=0.008) only for Candida albicans inhibitions results. All the other formulations of membranes and gels showed inhibition halos, but without statistically significant difference. The bioadhesive chitosan-based oral membrane with 2% chlorhexidine and 2% chlorhexidine gel were the most effective in inhibiting the tested microorganisms. (AU) | |
| FAPESP's process: | 13/07836-7 - Analysis and development of a dentin/pulpar biostimulating bandage (BBio) |
| Grantee: | Natalino Lourenço Neto |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |