| Full text | |
| Author(s): Show less - |
Ferreira, Jerenice E.
[1, 2]
;
Ferreira, Suzete C.
[3]
;
Almeida-Neto, Cesar
[3, 4]
;
Nishiya, Anna S.
[3]
;
Alencar, Cecilia S.
[5, 6, 7]
;
Gouveia, Gisele R.
[8]
;
Caiaffa-Filho, Helio
[2, 5]
;
Gomes, Helio
[5, 6, 7]
;
de Macedo Santosid, Raimunda Telma
[2]
;
Witkin, Steven S.
[9]
;
Mendrone-Junior, Alfredo
[3]
;
Sabino, Ester C.
[1]
Total Authors: 12
|
| Affiliation: | [1] Univ Sao Paulo, Med Sch, Inst Trop Med IMT, LIM 46 Lab Med Parasitol, Sao Paulo - Brazil
[2] Adolf Lutz Inst IAL, Pathol Ctr, Sao Paulo - Brazil
[3] FPS HSP, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Disciplina Ciencias Med, Sao Paulo - Brazil
[5] HCSP, DLC, Cent Lab Div, Sao Paulo - Brazil
[6] Univ Sao Paulo, Med Sch, Dept Clin Hosp, Clin Lab, Sao Paulo - Brazil
[7] Univ Sao Paulo, Med Sch, Dept Clin Hosp, LIM 03, Sao Paulo - Brazil
[8] Univ Sao Paulo, Fac Med, FMUSP, Sao Paulo - Brazil
[9] Weill Cornell Med, Dept Obstet & Gynecol, New York, NY - USA
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | PLoS One; v. 14, n. 1 JAN 14 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
The objective of this study was to characterize the prevalence of viral encephalitis due to arbovirus infection of the Togaviridae and Flaviviridae families in Sao Paulo, Brazil. A total of 500 cerebrospinal fluid (CSF) samples collected between August 2012 and January 2013, from patients with symptoms of acute encephalitis were analyzed. Findings suggestive of viral encephalitis-elevations in cell concentration, glucose and total protein-were observed in 234 (46.8%) samples, designated as Group 1. The remaining 266 samples comprised Group 2. All samples were tested for Flaviviruses (dengue virus 1, 2, 3 and 4, yellow fever virus and West Nile virus), Alphavirus (NS5 region) and enterovirus by RT-PCR and for herpesviruses and enteroviruses using CLART(-)Entherpex. A presumptive viral etiological agent was detected in 26 samples (5.2%), 18 (8.0%) in Group 1 and 8 (3.0%) in Group 2. In Group 1 human herpesviruses were detected in 9 cases, enteroviruses in 7 cases, dengue viruses (DENV) in 2 CSFs and St. Louis encephalitis virus (SLEV) in one case. In Group 2 there were 3 CSFs positive for human herpesviruses, 2 for enteroviruses, 2 for DENV and 1 for SLEV. Detection of arboviruses, even though present in a minority of infected patients, identifies these viruses as a probable etiological agent of encephalitis. This is of special concern in regions where this class of viruses is endemic and has been linked to other recent epidemics. (AU) | |