| Full text | |
| Author(s): |
Fernandes, Lais Silva
[1]
;
dos Santos, Neife Aparecida G.
[1]
;
Emerick, Guilherme Luz
[2]
;
dos Santos, Antonio Cardozo
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, FCFRP, Dept Anal Clin Toxicol & Bromatol, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Fed Mato Grosso ICS UFMT CUS, Inst Ciencias Saude, Sinop, MT - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | NEUROTOXICITY RESEARCH; v. 35, n. 1, p. 150-159, JAN 2019. |
| Web of Science Citations: | 4 |
| Abstract | |
Organophosphorus (OPs) compounds have been widely used in agriculture, industry, and household, and the neurotoxicity induced by them is still a cause of concern. The main toxic mechanism of OPs is the inhibition of acetylcholinesterase (AChE); however, the delayed neuropathy induced by OPs (OPIDN) is mediated by other mechanisms such as the irreversible inhibition of 70% of NTE activity (neuropathy target esterase) that leads to axonal degeneration. Liraglutide is a long-lasting GLP-1 analog clinically used as antidiabetic. Its neurotrophic and neuroprotective effects have been demonstrated in vitro and in experimental models of neurodegenerative diseases. As in OPIDN, axonal degeneration also plays a role in neurodegenerative diseases. Therefore, this study investigated the protective potential of liraglutide against the neurotoxicity of OPs by using mipafox as a neuropathic agent (at a concentration able to inhibit and age 70% of NTE activity) and a neuronal model with SH-SY5Y neuroblastoma cells, which express both esterases. Liraglutide protected cells against the neurotoxicity of mipafox by increasing neuritogenesis, the uptake of glucose, the levels of cytoskeleton proteins, and synaptic-plasticity modulators, besides decreasing the pro-inflammatory cytokine interleukin 1 and caspase-3 activity. This is the first study to suggest that liraglutide might induce beneficial effects against the delayed, non-cholinergic neurotoxicity of OPs. (AU) | |
| FAPESP's process: | 12/16319-3 - In vitro study of the mechanisms of neurotoxicity of the organophosphate trichlorfon: strategies for neuroprotection |
| Grantee: | Lais da Silva Fernandes |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/00168-6 - Organophosphate-induced delayed neuropathy: in vitro studies of mechanisms of neurotoxicity and neuroprotection |
| Grantee: | Guilherme Luz Emerick |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/26906-6 - Organophosphorus-induced delayed neuropathy: in vitro study of the mechanisms of neurotoxicity of trichlorfon and strategies of neuroprotection |
| Grantee: | Antonio Cardozo dos Santos |
| Support Opportunities: | Regular Research Grants |