| Full text | |
| Author(s): |
Total Authors: 5
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| Affiliation: | [1] Imperial Coll London, Dept Med, Glycosci Lab, London - England
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biol Celular & Mol & Bioagentes Patogen, Sao Paulo - Brazil
Total Affiliations: 2
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| Document type: | Journal article |
| Source: | DATA IN BRIEF; v. 5, p. 1035-1047, DEC 2015. |
| Web of Science Citations: | 5 |
| Abstract | |
This article contains data related to the researc.h article entitled ``Yeast-derived ArtinM shares structure, carbohydrate recognition, and biological effects with native ArtinM{''} by Cecilio et al. (2015) {[}1] ArtinM, a D-mannose-binding lectin isolated from the seeds of Artocarpus heterophyllus, exerts immunomodulatory and regenerative activities through its Carbohydrate Recognition Domain (CRD) (Souza et al., 2013; Mariano et al., 2014 {[}2,3]). The limited availability of the native lectin (n-ArtinM) led us to characterize a recombinant form of the protein, obtained by expression in Saccharomyces cerevisiae (y-ArtinM). We compared the carbohydrate binding specificities of y-ArtinM and n-ArtinM by analyzing the binding of biotinylated preparations of the two lectin forms using a neoglycolipid (NGL)-based glycan microarray. Data showed that y-ArtinM mirrored the specificity exhibited by n-ArtinM. (C) 2015 The Authors. Published by Elsevier Inc. (AU) | |
| FAPESP's process: | 09/16146-9 - Induced cell activation by ArtinM: interference of the quaternary structure of different recombinant forms on neutrophil functions and interaction with glycosylated receptors on surface of these cells. |
| Grantee: | Nerry Tatiana Cecilio |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/04088-0 - Lectin from pathogens |
| Grantee: | Maria Cristina Roque Antunes Barreira |
| Support Opportunities: | Research Projects - Thematic Grants |