Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

Full text
Author(s):
Patente, Thiago A. [1] ; Pinho, Mariana P. [1] ; Oliveira, Aline A. [1] ; Evangelista, Gabriela C. M. [1] ; Bergami-Santos, Patricia C. [1] ; Barbuto, Jose A. M. [1, 2]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Tumor Immunol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Med, Discipline Mol Med, Fac Med, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN IMMUNOLOGY; v. 9, JAN 21 2019.
Web of Science Citations: 6
Abstract

Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naive T cell activation and effector differentiation. They are, likewise, involved in the induction and maintenance of immune tolerance in homeostatic conditions. Their phenotypic and functional heterogeneity points to their great plasticity and ability to modulate, according to their microenvironment, the acquired immune response and, at the same time, makes their precise classification complex and frequently subject to reviews and improvement. This review will present general aspects of the DC physiology and classification and will address their potential and actual uses in the management of human disease, more specifically cancer, as therapeutic and monitoring tools. New combination treatments with the participation of DC will be also discussed. (AU)

FAPESP's process: 14/25988-1 - Analysis of the T cell repertoire in cancer patients: unveiling the antitumor immune response in humans
Grantee:Mariana Pereira Pinho
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/01137-8 - Analysis of the tumor-antigen specific T cell repertoire in healthy donors using T cell libraries
Grantee:Mariana Pereira Pinho
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/26437-9 - Glucose and glycated albumin effect over monocyte-induced dendritic cell (mo-DC) from heathy donors and type 1 diabetic patients.
Grantee:Thiago Andrade Patente
Support Opportunities: Scholarships in Brazil - Doctorate