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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Botulinum toxin A administration and orchiectomy in the treatment of canine benign prostatic hyperplasia

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Author(s):
Giuliano Queiroz Mostachio [1] ; Maricy Apparício [2] ; Tathiana Ferguson Motheo [3] ; Aracélle Elisane Alves [4] ; Wilter Ricardo Russiano Vicente [5]
Total Authors: 5
Affiliation:
[1] Centro Universitário de Rio Preto. Departamento de Clínica Cirúrgica de Pequenos Animais - Brasil
[2] Universidade Estadual Paulista. Faculdade de Ciências Agrárias e Veterinárias. Departamento de Reprodução Animal - Brasil
[3] Universidade Estadual Paulista. Faculdade de Ciências Agrárias e Veterinárias. Departamento de Reprodução Animal - Brasil
[4] Universidade Federal de Uberlândia. Faculdade de Medicina Veterinária. Departamento de Cirurgia - Brasil
[5] Universidade Estadual Paulista. Faculdade de Ciências Agrárias e Veterinárias. Departamento de Reprodução Animal - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Ciência Rural; v. 45, n. 9, p. 1654-1659, 2015-09-00.
Abstract

The pathogenesis of benign prostatic hyperplasia (BPH) is not completely known, however, dihydrotestosterone is a hormone involved in enlargement of the prostate. Recently, the effect of botulinum toxin A (BT-A) was investigated and has shown to induce atrophy of the gland. Based on that, the aims of this study were to compare the effects of administration of BT-A with orchiectomy in the treatment of BPH, in addition to assessing the effects of BT-A on libido and semen quality. Therefore, 16 sexually intact male dogs were submitted to orchiectomy or administration of 500U BT-A, and evaluated for 16 weeks. Orchiectomy presented excellent results, reducing the prostate volume up to 80%. Administration of BT-A did not interfered on libido, erection or semen characteristics. On the other hand, reduced significantly the prostate volume. The results suggest that intraprostatic injection of BT-A is an effective alternative treatment without adverse effects for valuable breeding dogs with BPH. However, this therapy showed lower reduction of prostate volume when compared to orchiectomy. (AU)