Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparative study of effects of Ginkgo biloba L. and Panax ginseng C.A. Meyer extract on the reproduction of Wistar male and female rats

Full text
Author(s):
L.B. Kuntze [1] ; A.K. Kondo [2] ; B.T.S. Bezerra [3] ; T. Pinto [4] ; I.C.C. Camargo [5]
Total Authors: 5
Affiliation:
[1] Universidade Estadual Paulista. Faculdade de Ciências e Letras. Departamento de Ciências Biológicas - Brasil
[2] Universidade Estadual Paulista. Faculdade de Ciências e Letras. Departamento de Ciências Biológicas - Brasil
[3] Universidade Estadual Paulista. Faculdade de Ciências e Letras. Departamento de Ciências Biológicas - Brasil
[4] Universidade Estadual Paulista. Faculdade de Ciências e Letras. Departamento de Ciências Biológicas - Brasil
[5] Universidade Estadual Paulista. Faculdade de Ciências e Letras. Departamento de Ciências Biológicas - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Revista Brasileira de Plantas Medicinais; v. 14, n. 1, p. 34-42, 2012-00-00.
Abstract

Ginkgo biloba and Panax ginseng are plants used in the traditional medicine. The aim of study was to analyse the gonadal histology of the Wistar male and female rats submitted to the treatments with extract of G. biloba (120 mg kg-1) or P. ginseng (200 mg kg-1), and to evaluate the reproductive and fetal parameters of female rats treated with the plants. The control group received physiological solution 0.9%. The treatments were administered by oral gavage, twice/day, during fifteen consecutive days. After this period, male (n=18) and female rats (n=18) were sacrificed and the gonads collected, weighed and processed for microscopic evaluation. Another females (n=18) were matted with not treated males for evaluation of fertility and pregnancy outcome. The results indicated that the male and feminine reproductive organs weight was not affected by treatments. The gonadal structure of male and female rats showed same histologic pattern in the three experimental groups. The pre-gestational treatment with the extracts not promoted alterations in the reproductive performance of dams and in the fetal parameters. It was concluded that the extract of P. ginseng or G. biloba not presented reproductive toxicity in the male and female rats. (AU)