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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Changes in the extracellular matrix due to diabetes and their impact on urinary continence

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Author(s):
Gabriela Marini [1] ; Jaqueline de Carvalho Rinaldi [2] ; Débora Cristina Damasceno [3] ; Sérgio Luis Felisbino [4] ; Marilza Vieira Cunha Rudge [5]
Total Authors: 5
Affiliation:
[1] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina de Botucatu. Departamento de Ginecologia e Obstetrícia - Brasil
[2] Universidade Estadual Paulista Julio de Mesquita Filho. Instituto de Biociências de Botucatu. Departamento de Morfologia - Brasil
[3] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina de Botucatu. Departamento de Ginecologia e Obstetrícia - Brasil
[4] Universidade Estadual Paulista Julio de Mesquita Filho. Instituto de Biociências de Botucatu. Departamento de Morfologia - Brasil
[5] Universidade Estadual Paulista Julio de Mesquita Filho. Faculdade de Medicina de Botucatu. Departamento de Ginecologia e Obstetrícia - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Revista Brasileira de Ginecologia e Obstetrícia; v. 36, n. 7, p. 328-333, 2014-07-00.
Abstract

The prevalence of urinary incontinence in diabetic pregnant women is significantly high two years after cesarean section. Incontinence can be the most common consequence of hyperglycemia compared to other complications. Thus, identifying the risk factors for the development of urinary incontinence in diabetes is the major aim in the prevention of this very common condition. Recent surveys have shown that not only muscle but also the urethral extracellular matrix play an important role in the mechanism of urinary continence. Translational work on rats by our research group showed that diabetes during pregnancy damages the extracellular matrix and urethral striated muscle, a fact that may explain the high prevalence of urinary incontinence and pelvic floor dysfunction in women with gestational diabetes mellitus. Diabetes affects the expression, organization and change in extracellular matrix components in different organs, and tissue remodeling and fibrosis appear to be a direct consequence of it. Therefore, understanding the impact of modifiable risk factors, such as diabetes, which involves using preventive strategies, can reduce the rates of urinary incontinence and the health care costs, and improve the quality of life of women, especially during pregnancy and postpartum. (AU)

FAPESP's process: 10/11703-4 - Effect of Streptozotocin-induced diabetes on extracellular matrix and urethral striated muscle of pregnant rats
Grantee:Marilza Vieira Cunha Rudge
Support Opportunities: Regular Research Grants
FAPESP's process: 10/10740-3 - EFFECTS OF STREPTOZOTOCIN-INDUCED DIABETES ON EXTRACELLULAR MATRIX AND URETHRAL STRIATED MUSCLE OF PREGNANT RATS
Grantee:Gabriela Marini Prata
Support Opportunities: Scholarships in Brazil - Doctorate