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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria

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Author(s):
Scarim, Caue Benito [1] ; Jornada, Daniela Hartmann [1] ; Mendes Machado, Marcella Gabrielle [1] ; Riberio Ferreira, Carla Maria [1] ; dos Santos, Jean Leandro [1] ; Chung, Man Chin [1]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; v. 162, p. 378-395, JAN 15 2019.
Web of Science Citations: 5
Abstract

Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. In this review article, we critically analyzed the contribution of these scaffolds to medicinal chemistry in the last five years, focusing on tropical infectious diseases, such as Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria. We also present perspectives for their use in drug design in order to contribute to the development of new drugs. (C) 2018 Elsevier Masson SAS. All rights reserved. (AU)

FAPESP's process: 16/10847-9 - Hydroxymethylnitrofurazone (NFOH): activity study in chronic phase of Chagas' Disease in an animal model and synthesis of soluble derivatives
Grantee:Cauê Benito Scarim
Support Opportunities: Scholarships in Brazil - Doctorate