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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thyroid function disruptors: from nature to chemicals

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Author(s):
Oliveira, Karen Jesus [1] ; Chiamolera, Maria Isabel [2] ; Giannocco, Gisele [3, 2] ; Pazos-Moura, Carmen Cabanelas [4] ; Ortiga-Carvalho, Tania Maria [5]
Total Authors: 5
Affiliation:
[1] Univ Fed Fluminense, Lab Fisiol Endocrina & Metabol, Dept Fisiol & Farmacol, Rio De Janeiro - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Lab Endocrinol Mol & Translac, Disciplina Endocrinol & Metabol, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Ciencias Biol, Diadema - Brazil
[4] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Lab Endocrinol Mol, Rio De Janeiro, RJ - Brazil
[5] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Lab Endocrinol Translac, Rio De Janeiro, RJ - Brazil
Total Affiliations: 5
Document type: Review article
Source: JOURNAL OF MOLECULAR ENDOCRINOLOGY; v. 62, n. 1, p. R1-R19, JAN 2019.
Web of Science Citations: 1
Abstract

The modern concept of thyroid disruptors includes synthetic chemicals and bioactive compounds from food that interfere with any aspect of the hypot halamus-pituitarythyroid axis, thyroid hormone biosynthesis and secretion, blood and transmembrane transport, metabolism and local actions of thyroid hormones. This review highlights relevant disruptors that affect populations through their diet: directly from food itself (fish oil and polyunsaturated fatty acids, pepper, coffee, cinnamon and resveratrol/grapes), through vegetable cultivation (pesticides) and from containers for food storage and cooking (bisphenol A, phthalates and polybrominated diphenyl ethers). Due to the vital role of thyroid hormones during every stage of life, we r eview effects from the gestational period to adulthood, including evidence from in vitro studies, rodent models, human trials and epidemiological studies. (AU)

FAPESP's process: 13/26851-7 - In vivo study of the effects of the endocrine disruptors glyphosate and bisphenol-A on the hypothalamic-pituitary-thyroid axis
Grantee:Maria Izabel Chiamolera
Support Opportunities: Regular Research Grants