Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice

Author(s)

Joseph, Biju ^[1] ; Shimojo, Guilherme ^[1] ; Li, Zhifeng ^[1] ; del Rocio Thompson-Bonilla, Maria ^{[1, 2]} ; Shah, Roshan ^[1] ; Kanashiro, Alexandre ^{[3, 1]} ; Salgado, Helio C. ^[3] ; Ulloa, Luis ^{[1, 4]}

Affiliation

^[1] Rutgers New Jersey Med Sch, Dept Surg, Newark, NJ 07103 - USA

^[2] Hosp October 1st ISSSTE, 1669 Natl Polytech Inst Ave, Mexico City, DF - Mexico

^[3] Univ Sao Paulo, Sch Med, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil

^[4] Rutgers New Jersey Med Sch, Ctr Immun & Inflammat, Newark, NJ 07103 - USA

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 9, JAN 30 2019.
• Web of Science Citations: 2

Abstract

Sepsis is a leading cause of death in hospitalized patients. Many experimental treatments may have failed in clinical trials for sepsis, in part, because they focused on immune responses of healthy animals that did not mimic the metabolic settings of septic patients. Epidemiological studies show an association between metabolic and immune alterations and over 1/3 of septic patients are diabetic, but the mechanism linking these systems is unknown. Here, we report that metabolic fasting increased systemic inflammation and worsened survival in experimental sepsis. Feeding and administration of glucose in fasted mice activated the vagal tone without affecting blood pressure. Vagal stimulation attenuated hyperglycemia and serum TNF levels in sham but only hyperglycemia in splenectomized mice. Vagal stimulation induced the production of dopamine from the adrenal glands. Experimental diabetes increased hyperglycemia and systemic inflammation in experimental sepsis. Fenoldopam, a specific dopaminergic type-1 agonist, attenuated hyperglycemia and systemic inflammation in diabetic endotoxemic mice. These results indicate that glucose activates vagal control of hyperglycemia and inflammation in fasted septic mice via dopamine. (AU)

• FAPESP's process: 11/20343-4 - Antiinflammatory cholinergic pathway: the role of neuroimmunomodulation in the control of inflammatory response
• Grantee: Alexandre Kanashiro
• Support Opportunities: Research Grants - Young Investigators Grants