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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of the tolerance to vancomycin in 395 oxacillin-resistant Staphylococcus aureus strains isolated from Brazilian hospitals

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Author(s):
Geraldo A. Oliveira [1] ; Sabrina S. Okada [2] ; Regiane S. Guenta [3] ; Elsa M. Mamizuka [4]
Total Authors: 4
Affiliation:
[1] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
[2] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
[3] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
[4] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
Total Affiliations: 4
Document type: Journal article
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial; v. 37, n. 4, p. 239-246, 2001-00-00.
Abstract

The objective of this study was to evaluate the presence of tolerance to vancomycin in oxacillin-resistant Staphylococcus aureus (Orsa) strains isolated from four hospitals in the city of São Paulo. From October/1998 to May/2000 we analysed 395 Orsa strains isolated from hospitalized patients. MIC and MBC to vancomycin were determined as standardised by National Committee for Clinical Laboratory Standards (NCCLS). Tolerance was defined as the ratio MBC/MIC > or = 32. The results showed that 10.4% of the Orsa strains presented a MIC of 0.5µg/mL for vancomycin, 41.3% presented a MIC of 1µg/mL, 42.2% a MIC of 2µg/mL and 6.1% a MIC of 4µg/mL. On average, 49,1% of the Orsa presented tolerance to vancomycin. We conclude that the tolerance to vancomycin amongst the Orsa strains was considered high. These high levels of tolerance augment the chances of failure in the treatment with vancomycin, as well as enhancing the risk of emergence of vancomycin-intermediate Staphylococcus aureus. (AU)