| Full text | |
| Author(s): |
Cleber A Leite
[1]
;
Nádia SC Bertoncello
[2]
;
Ingrid KM Watanabe
[3]
;
Fernanda B Fernandes
[4]
;
Maria Claudina C Andrade
[5]
;
Fernanda A Ronchi
[6]
;
Danielle Y Arita
[7]
;
Fernanda K Marcondes
[8]
;
Tatiana S Cunha
[9]
;
Dulce E Casarini
[10]
Total Authors: 10
|
| Affiliation: | [1] Universidade Federal de São Paulo - Brasil
[2] Universidade Federal de São Paulo - Brasil
[3] Universidade Federal de São Paulo - Brasil
[4] Universidade Federal de São Paulo - Brasil
[5] Universidade Federal de São Paulo - Brasil
[6] Universidade Federal de São Paulo - Brasil
[7] Universidade Federal de São Paulo - Brasil
[8] Universidade Estadual de Campinas - Brasil
[9] Universidade Federal de São Paulo - Brasil
[10] Universidade Federal de São Paulo - Brasil
Total Affiliations: 10
|
| Document type: | Journal article |
| Source: | J. Bras. Nefrol.; v. 39, n. 1, p. 11-14, 2017-03-00. |
| Abstract | |
Abstract Introduction: Hypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition. Objective: The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE. Methods: To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham. Results and Discussion: Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery. Conclusion: Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration. (AU) | |
| FAPESP's process: | 02/13290-2 - Angiotensin I: converting enzyme isoform (90 kDa), potential genetic marker of hypertension: processing, molecular and functional characterization, and genetic segregation |
| Grantee: | Dulce Elena Casarini |
| Support Opportunities: | Research Projects - Thematic Grants |