Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development and validation of analytical methodology by HPLC-IR for evaluation of artemisinin on Artemisa annua L

Full text
Author(s):
Renata Maria dos Santos Celeghini [1] ; Ilza Maria de Oliveira Sousa [2] ; Ana Paula da Silva [3] ; Rodney Alexandre Ferreira Rodrigues [4] ; Mary Ann Foglio [5]
Total Authors: 5
Affiliation:
[1] Universidade Estadual de Campinas. Faculdade de Engenharia de Alimentos. Departamento de Tecnologia de Alimentos - Brasil
[2] Universidade Estadual de Campinas. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas - Brasil
[3] Universidade Estadual de Campinas. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas - Brasil
[4] Universidade Estadual de Campinas. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas - Brasil
[5] Universidade Estadual de Campinas. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Química Nova; v. 32, n. 4, p. 875-878, 2009-00-00.
Abstract

The aim of this work was to develop and validate an analytical methodology for determination of artemisinin used as antimalaric. The method was based on high performace liquid chromatography, using a CN column with mobile phase composed of methanol : H2O 50:50 (V/V). The results showed that the method presented linearity from 50 to 1500 µg/mL. It was considered selective, accurate, precise according to the specific resolution from ANVISA, the Brazilian regulatory agency. (AU)