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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Production of monoclonal antibodies anti-Taenia crassiceps cysticerci with cross-reactivity with Taenia solium antigens

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Author(s):
Noeli M. ESPÍNDOLA [1] ; Elizabeth N. DE GASPARI [2] ; Paulo M. NAKAMURA [3] ; Adelaide J. VAZ [4]
Total Authors: 4
Affiliation:
[1] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas - Brasil
[2] Instituto Adolfo Lutz - Brasil
[3] Instituto Adolfo Lutz - Brasil
[4] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Revista do Instituto de Medicina Tropical de São Paulo; v. 42, n. 3, p. 175-177, 2000-06-00.
Abstract

We describe the production of the potential monoclonal antibodies (MoAbs) using BALB/c mice immunized with vesicular fluid (VF)-Tcra (T. crassiceps) antigen. Immune sera presented anti-VF-Tcra (<20kD) IgG and IgM antibodies with cross-reactivity with T. solium (Tso) antigen (8-12, 14, and 18 kD). After cell fusion, we selected 33 anti-Tcra and anti-Tso reactive IgM-clones and 53 anti-Tcra specific IgG-clones, 5 of them also recognizing Tso antigens. Two clones identified the 8-14 and 18kD peptides of VF-Tcra. (AU)