| Full text | |
| Author(s): |
Guilherme Felipe dos Santos Fernandes
;
Chung Man Chin
[2]
;
Jean Leandro dos Santos
Total Authors: 3
|
| Document type: | Journal article |
| Source: | Química Nova; v. 40, n. 5, p. 572-585, 2017-06-00. |
| Abstract | |
Tuberculosis (TB) is an infectious disease caused by mycobacteria from the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization (WHO) aims to reduce the number of TB cases worldwide in the coming years. Nevertheless, the increasing number of multidrug-resistant (MDR-TB) and extensive-drug resistance (XDR-TB) strains, and the ineffectiveness of the current treatment in latent tuberculosis are challenges to be overcome. In this review, we will demonstrate the recent advances in the tuberculosis drug discovery, focusing the research of new molecular targets in the Mycobacterium tuberculosis. Among the promising targets described herein, we highlight those, which act in different pathways in the mycobacteria, such as energy metabolism, cell wall biosynthesis, DNA synthesis, iron metabolism and transport through membranes. Furthermore, bioactive compounds discovered using phenotypic assays screening and validated through genetic approaches are also presented. (AU) | |
| FAPESP's process: | 14/24811-0 - Design and synthesis of new 1,4-di-N-oxide quinoxaline as antitubercular compounds to treat multi drug-resistant (MDR) and latent tuberculosis |
| Grantee: | Guilherme Felipe dos Santos Fernandes |
| Support Opportunities: | Scholarships abroad - Research Internship - Master's degree |
| FAPESP's process: | 14/02240-1 - Design, Synthesis and anti Mycobacterium tuberculosis activity of new N-oxides derivatives |
| Grantee: | Guilherme Felipe dos Santos Fernandes |
| Support Opportunities: | Scholarships in Brazil - Master |