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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

COMPARISON OF THE LEVELS OF C-REACTIVE PROTEIN, GLP-1 AND GLP-2 AMONG INDIVIDUALS WITH DIABETES, MORBID OBESITY AND HEALTHY CONTROLS: AN EXPLORATORY STUDY

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Author(s):
Everton CAZZO [1] ; José Carlos PAREJA [2] ; Elinton Adami CHAIM [3] ; Cláudio Saddy Rodrigues COY [4] ; Daniéla Oliveira MAGRO [5]
Total Authors: 5
Affiliation:
[1] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Cirurgia - Brasil
[2] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Cirurgia - Brasil
[3] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Cirurgia - Brasil
[4] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Cirurgia - Brasil
[5] Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Cirurgia - Brasil
Total Affiliations: 5
Document type: Journal article
Source: Arq. Gastroenterol.; v. 55, n. 1, p. 72-77, 2018-03-00.
Abstract

ABSTRACT BACKGROUND: The glucagon-like peptides 1 and 2 (GLP-1/GLP-2) are gut hormones that may directly affect the glucose homeostasis and their activity seems to be significantly affected by chronic inflammation. OBJECTIVE: To evaluate the postprandial levels of glucagon-like peptides 1 and 2 (GLP-1/GLP-2), C-reactive protein (CRP), and the postprandial glucose and insulin levels among individuals with obesity, type 2 diabetes, and healthy controls. METHODS: An exploratory cross-sectional study, which involved individuals awaiting for bariatric/metabolic surgery and healthy controls. Postprandial levels of GLP-1, GLP-2, glucose, and insulin were obtained after a standard meal tolerance test. Inflammation was assessed by means of CRP. RESULTS: There were 30 individuals enrolled in the study, divided into three groups: non-diabetic with morbid obesity (NDO; n=11 individuals), diabetic with mild obesity (T2D; n=12 individuals), and healthy controls (C; n=7 individuals). The mean CRP levels were significantly higher in the NDO group (6.6±4.7 mg/dL) than in the T2D (3.3±2.2 mg/dL) and C groups (2.5±3.2 mg/dL) (P=0.038). The GLP-1 levels following standard meal tolerance test and the area under the curve of GLP-1 did not differ among the three groups. The GLP-2 levels were significantly lower in the NDO and T2D than in the C group following standard meal tolerance test at all the times evaluated. The area under the curve of the GLP-2 was significantly lower in the NDO and T2D groups than in the C group (P=0.05 and P=0.01, respectively). CONCLUSION: GLP-2 levels were impaired in the individuals with obesity and diabetes. This mechanism seems to be enrolled in preventing the worsening of the glucose homeostasis in these individuals. (AU)