| Full text | |
| Author(s): |
Beatriz Duarte Palma
[1]
;
Paula Ayako Tiba
[2]
;
Ricardo Borges Machado
[3]
;
Sergio Tufik
[4]
;
Deborah Suchecki
[5]
Total Authors: 5
|
| Affiliation: | [1] Universidade Federal de São Paulo. Departamento de Psicobiologia - Brasil
[2] Universidade Federal de São Paulo. Departamento de Psicobiologia - Brasil
[3] Universidade Federal de São Paulo. Departamento de Psicobiologia - Brasil
[4] Universidade Federal de São Paulo. Departamento de Psicobiologia - Brasil
[5] Universidade Federal de São Paulo. Departamento de Psicobiologia - Brasil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Revista Brasileira de Psiquiatria; v. 29, p. s33-s38, 2007-05-00. |
| Abstract | |
OBJECTIVE: To review the literature on the interaction between sleep and the immune system. METHOD: A search on Web of Science and Pubmed database including the keywords sleep, sleep deprivation, stress, hypothalamic-pituitary-adrenal axis, immune system, and autoimmune diseases. RESULTS: On Web of Science, 588 publications were retrieved; 61 references, more significant and closer to our objective, were used, including original articles and review papers. CONCLUSION: Sleep deprivation and immune system exert a bidirectional influence on each other. Since sleep deprivation is considered a stressor, inasmuch as it induces elevation of cortisol or corticosterone levels in humans and rodents, respectively, and given the well-known immunosuppressive effect of glucocorticoids, we propose that increased activation of the hypothalamic-pituitary-adrenal axis is a major mediator of the immune alterations observed in patients with insomnia or in sleep deprived subjects. (AU) | |
| FAPESP's process: | 98/14303-3 - Center for Sleep Studies |
| Grantee: | Sergio Tufik |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |