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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

IGF-1 assessed by pubertal status has the best positive predictive power for GH deficiency diagnosis in peripubertal children

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Author(s):
Inoue-Lima, Thais H. [1] ; Vasques, Gabriela A. [1, 2] ; Scalco, Renata C. [1, 2] ; Nakaguma, Marilena [1] ; Mendonca, Berenice B. [1] ; Arnhold, Ivo J. P. [1] ; Jorge, Alexander A. L. [3, 1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Unidade Endocrinol Desenvolvimento LIM 42, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin, Unidade Endocrinol Genet LIM 25, Sao Paulo - Brazil
[3] Univ Sao Paulo, USP LIM 25, Fac Med, Unidade Endocrinol Genet LIM 25, Hosp Clin, Av Dr Arnaldo 455, 5 Andar Sala 5340, BR-01246903 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM; v. 32, n. 2, p. 173-179, FEB 2019.
Web of Science Citations: 0
Abstract

Background: When evaluating peripubertal short stature patients, the interpretation of insulin-like growth factor 1 (IGF-1) levels based on chronological age (CA) can be inaccurate due to the influence of sex steroids and, presently, there is no evidence to support the assessment of IGF-1 values according to bone age (BA) and pubertal status (PS). Our objective was to assess the discriminatory performance of IGF-1 levels based on CA, BA and PS in the diagnosis of growth hormone (GH) deficiency. Methods: We evaluated IGF-1 levels from 154 peripubertal short stature patients classified as GH deficient (GHD, n = 23) or non-GHD (n =131). IGF-1 was assayed by a chemiluminescent immunometric assay and transformed into standard deviation scores (SDS) according to CA (IGF1-SDS-CA), BA (IGF-1-SDS-BA) and PS (IGF-1-SDS-PS). Results: The performances of IGF-1-SDS-CA, IGF-1-SDS-BA and IGF-1-SDS-PS in the receiver operator characteristics (ROC) curves were similar. There were greater accuracy and specificity of IGF-1-SDS-PS (98A% and 93.3%, respectively) and IGF-1-SDS-BA (92.7% and 90.1%, respectively) when compared to IGF-1-SDS-CA (65.6% and 69.5%, respectively). The post-test probability of the IGF-1-SDS was also improved when compared to PS and BA - 44.8% (IGF-1-SDS-PS), 16.8% (IGF-1-SDS-BA) and 5.1% (IGF-1-SDS-CA), with similar negative predictive values. Conclusions: The evaluation of IGF-1 levels based on CA has a higher sensitivity than those based on BA or PS, which justify its use as a screening tool. Additionally, IGF-1 assessed by PS has the best positive predictive power for GHD diagnosis in peripubertal age and could reduce the necessity of a second Gil stimulation test. (AU)

FAPESP's process: 13/03236-5 - New approaches and methodologies in molecular-genetic studies of growth and pubertal development disorders
Grantee:Alexander Augusto de Lima Jorge
Support type: Research Projects - Thematic Grants