Synthesis of (z)-5-(4-fluorobenzylidene)thiazolidine-2,4-dione, an intermediate of...
| Full text | |
| Author(s): |
de Oliveira Silva, Renan Rodrigues
[1]
;
Cuesta Calvo, Paulo Victor
[1]
;
da Silva, Milena Fernandes
[2]
;
Solisio, Carlo
[3]
;
Converti, Attilio
[3]
;
Alves Palma, Mauri Sergio
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Dept Biochem & Pharmaceut Technol, Ave Prof Lineu Prestes 580, Bloco 16, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Fed Pernambuco, Biosci Ctr, Ave Prof Moraes Rego 1235, Cidade Univ, BR-50670901 Recife, PE - Brazil
[3] Genoa Univ, Dept Civil Chem & Environm Engn, Pole Chem Engn, Via Opera Pia 15, I-16145 Genoa - Italy
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | CHEMICAL ENGINEERING & TECHNOLOGY; v. 42, n. 2, p. 465-473, FEB 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Microreactor technology can help to reduce the time to market new drugs. It was applied to produce (Z)-5-benzylidenethiazolidine-2,4-dione, a heterocyclic intermediate in the synthesis of various drugs. Ethanol was the optimum solvent and piperidine the best catalyst in the batch process. The continuous/microreactor process exhibited a much better performance than the batch process. The productivity, which was strongly influenced by solvent and temperature, reached a maximum at 160 degrees C using methanol as solvent. A kinetic/thermodynamic study indicated that the reaction followed the second-order model and allowed estimating its main thermodynamic parameters. A product recovery protocol was finally proposed. The microreactor proved an efficient alternative to the batch reactor in scaling up the production of active pharmaceutical ingredients. (AU) | |
| FAPESP's process: | 14/07757-2 - Micro-reactors in the synthesis of pharmaceuticals |
| Grantee: | Mauri Sergio Alves Palma |
| Support type: | Regular Research Grants |