Inflammation and quality of life in later life: findings from the health, well-being and aging study (SABE)

Author(s)

Roediger, Manuela de Almeida ^{[1, 2]} ; Nunes Marucci, Maria de Fatima ^[3] ; Duim, Etienne Larissa ^[1] ; Ferreira Santos, Jair Licio ^[4] ; de Oliveira Duarte, Yeda Aparecida ^[5] ; de Oliveira, Cesar ^[6]

Affiliation

^[1] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Publ Hlth FSP, Dept Nutr, Ave Doutor Arnaldo 715, BR-01246904 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Social Med, Ribeirao Preto - Brazil

^[5] Univ Sao Paulo, Dept Nursing Med Surg, Sao Paulo - Brazil

^[6] UCL, Dept Epidemiol & Publ Hlth, London - England

• Document type: Journal article
• Source: HEALTH AND QUALITY OF LIFE OUTCOMES; v. 17, FEB 6 2019.
• Web of Science Citations: 3

Abstract

BackgroundFew studies have specifically investigated the inverse relationship between reduced quality of life in different domains and elevated C-reactive protein (CRP) serum levels in older adults. Therefore, this study investigates the cross-sectional association between quality of life and inflammation in older Brazilian adults.MethodsData were collected from 1255 participants from the third wave (2010) of the Brazilian Health, Well-being and Aging study (SABE), a community-based cohort study of aging. Inflammation was assessed using CRP serum levels and quality of life (QoL) was measured using the 12-item Short-Form Health Survey (SF-12) questionnaire. The covariates included age, sex, education level, financial sufficiency, number of non-communicable diseases, self-reported doctor diagnosed diseases, Activity of Daily Living (ADL) difficulties, Body Mass Index (BMI), and waist circumference.ResultsThe fully adjusted models showed that older adults with low scores in the physical domain of the SF12 (OR 1.34, 95%CI 1.02;1.77) and high BMI values (>30) (OR 2.05, 95%CI 1.50;2.81) were more likely to present high CRP serum levels.ConclusionOur findings suggest a significant association of lower scores in the physical domain of quality of life and the presence of obesity with high CRP serum levels. (AU)

• FAPESP's process: 15/15224-7 - Effects of serum levels of cardiometabolic, hormonal, inflammatory and nutritional biomarkers on the body composition in different cohorts of Brazilian older people domiciled
• Grantee: Manuela de Almeida Roediger
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/19696-3 - Ageing and functional ability: an analysis of trajectories
• Grantee: Etienne Larissa Duim Negrini
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 09/53778-3 - SABE Study 2010: Health, well-being and aging
• Grantee: Maria Lúcia Lebrão
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 05/54947-2 - SABE study - 2005: well-being and ageing: longitudinal study of living conditions and health of elderly in the municipality of São Paulo
• Grantee: Ruy Laurenti
• Support Opportunities: Research Projects - Thematic Grants