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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanostructured mixed Ni/Pt hydroxides electrodes for BIA-amperometry determination of hydralazine

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Azeredo, Nathalia F. B. [1] ; Rossini, Pamela O. [1] ; Goncalves, Josue M. [1] ; Assis, Geovanne L. [1] ; Araki, Koiti [1] ; Angnes, Lucio [1]
Total Authors: 6
[1] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of the Taiwan Institute of Chemical Engineers; v. 95, p. 475-480, FEB 2019.
Web of Science Citations: 1

A fluorine doped tin oxide (FTO) coated glass modified with mixed nickel/platinum hydroxide nanoparticles (alpha-Ni0.98Pt0.02(OH)(2)) was utilized as BIA amperometric sensor for fast determination of hydralazine in pharmaceutical formulations. The new electrode material was characterized by X-ray diffraction (XRD), thermal analysis (TG-DTA), transmission electron microscopy (TEM) and voltammetry, exhibiting high conductivity and enhanced activity compared to the FTO electrode without modification. The alpha-Ni0.98Pt0.02(OH)(2) electrode associated with batch injection analysis (BIA) showed good amperometric response to hydralazine, attaining detection and quantification limits of 5.93 x 10(-6) and 2.0 x 10(-5) mol/L, respectively, besides elevated analytical frequency (240 samples/h). The amount of hydralazine in real pharmaceutical samples were analyzed by BIA/amperometry and UV-Vis spectrophotometry, the method recommended by the United States Pharmacopeia, giving comparable results. In fact, both methods presented very good concordance (difference of 0.8%) indicating that the BIA method associated with the features of alpha-Ni0.98Pt0.02(OH)(2) electrode is thus well-suited for electroanalytical purposes, and can be employed for determination of hydralazine in pharmaceuticals. (C) 2018 Published by Elsevier B.V. on behalf of Taiwan Institute of Chemical Engineers. (AU)

FAPESP's process: 17/13137-5 - Formation and properties of hemiesters of carbonic acid in aqueous medium
Grantee:Claudimir Lucio Do Lago
Support type: Research Projects - Thematic Grants