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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mitochondrial functions and melatonin: a tour of the reproductive cancers

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de Almeida Chuffa, Luiz Gustavo [1] ; Ferreira Seiva, Fabio Rodrigues [2] ; Cucielo, Maira Smaniotto [1] ; Silveira, Henrique Spaulonci [1] ; Reiter, Russel J. [3] ; Lupi, Luiz Antonio [1]
Total Authors: 6
[1] Sao Paulo State Univ, UNESP, Dept Anat, Inst Biosci Botucatu, POB 18618-689, Botucatu, SP - Brazil
[2] Univ Estadual Norte Parana, Dept Biol & Technol, UENP CLM, Bandeirantes, Parana - Brazil
[3] UTHealth, Dept Cellular & Struct Biol, San Antonio, TX 78229 - USA
Total Affiliations: 3
Document type: Review article
Source: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 76, n. 5, p. 837-863, MAR 2019.
Web of Science Citations: 2

Cancers of the reproductive organs have a strong association with mitochondrial defects, and a deeper understanding of the role of this organelle in preneoplastic-neoplastic changes is important to determine the appropriate therapeutic intervention. Mitochondria are involved in events during cancer development, including metabolic and oxidative status, acquisition of metastatic potential, resistance to chemotherapy, apoptosis, and others. Because of their origin from melatonin-producing bacteria, mitochondria are speculated to produce melatonin and its derivatives at high levels; in addition, exogenously administered melatonin accumulates in the mitochondria against a concentration gradient. Melatonin is transported into tumor cell by GLUT/SLC2A and/or by the PEPT1/2 transporters, and plays beneficial roles in mitochondrial homeostasis, such as influencing oxidative phosphorylation and electron flux, ATP synthesis, bioenergetics, calcium influx, and mitochondrial permeability transition pore. Moreover, melatonin promotes mitochondrial homeostasis by regulating nuclear DNA and mtDNA transcriptional activities. This review focuses on the main functions of melatonin on mitochondrial processes, and reviews from a mechanistic standpoint, how mitochondrial crosstalk evolved in ovarian, endometrial, cervical, breast, and prostate cancers relative to melatonin's known actions. We put emphasis on signaling pathways whereby melatonin interferes within cancer-cell mitochondria after its administration. Depending on subtype and intratumor metabolic heterogeneity, melatonin seems to be helpful in promoting apoptosis, anti-proliferation, pro-oxidation, metabolic shifting, inhibiting neovasculogenesis and controlling inflammation, and restoration of chemosensitivity. This results in attenuation of development, progression, and metastatic potential of reproductive cancers, in addition to lowering the risk of recurrence and improving the life quality of patients. (AU)

FAPESP's process: 16/03993-9 - Effect of P-MAPA immunomodulator associated to interleukin-12 on Ovarian Cancer: in vitro and in vivo approaches involving the inflammatory process and immune system
Grantee:Luiz Gustavo de Almeida Chuffa
Support type: Regular Research Grants