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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Identification of potential target genes associated with the reversion of androgen-dependent skeletal muscle atrophy

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Author(s):
Coelho, Priscila de O. [1] ; Guarnier, Flavia A. [2] ; Figueiredo, Leonardo Bruno [3] ; Zaramela, Livia S. [1, 4] ; Pacini, Enio S. A. [3] ; Godinho, Rosely O. [3] ; Gomes, Marcelo D. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ave Bandeirantes 39000, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Estadual Londrina, Lab Pathophysiol & Muscle Adaptat, Londrina - Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Dept Pharmacol, Sao Paulo - Brazil
[4] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 - USA
Total Affiliations: 4
Document type: Journal article
Source: Archives of Biochemistry and Biophysics; v. 663, p. 173-182, MAR 15 2019.
Web of Science Citations: 0
Abstract

Muscle wasting or atrophy is extensively associated with human systemic diseases including diabetes, cancer, and kidney failure. Accumulating evidence from transcriptional profiles has noted that a common set of genes, termed atrogenes, is modulated in atrophying muscles. However, the transcriptional changes that trigger the reversion or attenuation of muscle atrophy have not been characterized at the molecular level until now. Here, we applied cDNA microarrays to investigate the transcriptional response of androgen-sensitive Levator ani muscle (LA) during atrophy reversion. Most of the differentially expressed genes behaved as atrogenes and responded to castration-induced atrophy. However, seven genes (APLN, DUSP5, IGF1, PIK3IP1, KLHL38, PI15, and MKL1) did not respond to castration but instead responded exclusively to testosterone replacement. Considering that almost all proteins encoded by these genes are associated with the reversion of atrophy and may function as regulators of cell proliferation/growth, our results provide new perspectives on the existence of anti-atrogenes. (AU)

FAPESP's process: 15/07019-4 - Role of the extracellular cyclic AMP-adenosine pathway in the respiratory and neuromuscular physiology and physiopathology
Grantee:Rosely Oliveira Godinho
Support Opportunities: Regular Research Grants
FAPESP's process: 14/10898-7 - High-throughput RNAi library screening to identify novel regulators of ERKs
Grantee:Marcelo Damário Gomes
Support Opportunities: Regular Research Grants
FAPESP's process: 11/07487-7 - Identification and characterization of Lsm-binding non-coding RNAs in the extremophile Halobacterium salinarum
Grantee:Lívia Soares Zaramela
Support Opportunities: Scholarships in Brazil - Doctorate