Quinoline-derivative coordination compounds as potential applications to antibacterial and antineoplasic drugs

Author(s)

Chagas, Camila dos Santos ^[1] ; Fonseca, Fernando L. A. ^{[1, 2]} ; Bagatin, Izilda A. ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Lab Quim Calixarenos Espectroscopia Mol & Catalis, Inst Ciencias Ambientais Quim & Farmaceut, Rua Prof Arthur Riedel 275, BR-09972270 Diadema, SP - Brazil

^[2] Fac Med ABC, Lab Anal Clin, Av Principe Gales 821, BR-09060650 Santo Andre, SP - Brazil

• Document type: Journal article
• Source: Materials Science & Engineering C-Materials for Biological Applications; v. 98, p. 1043-1052, MAY 2019.
• Web of Science Citations: 0

Abstract

Quinoline-derivative coordination compounds were synthesized with Zn(II), Al(III), Cu(II), Ru(II) producing 1-4 compounds using 5-nitro-8-hydroxyquinoline and 5-8 compounds using 5-chloro-8-hydroxyquinoline. These coordination compounds were characterized by elemental analysis and H-1 NMR, IR, UV-Vis and fluorescence spectroscopies, representing the coherent data matched all compounds. Myelotoxicity data, as well as the biochemical data, depicted the compounds have low cytotoxicity towards the blood cells. All coordination compounds displayed slight antimicrobial activity against E. coil, S. aureus, P. aeruginosa and E. faecalis; {[}RuCl(NO) (5-chloro-8-oxyquinoline)(2)] compound (8) represent the best result to inhibitions of Gram-positive and Gramnegative bacteria. Antineoplasic action depicted the {[}Ru(NO)(5-nitro-8-oxyquinoline)(2)Cl] compound (4) as a potential chemotherapeutic agent against MCF-7 (a breast cancer cell line), compared to cisplatin (Platistine (R) CS) and cyclophosphamide (Genuxal (R)) drugs. (AU)

• FAPESP's process: 15/20485-4 - Calixarenes and iminic ligands developed for sensors, luminescent and bioinorganic compounds
• Grantee: Izilda Aparecida Bagatin
• Support Opportunities: Regular Research Grants