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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hippocampal and cortical communication around micro-arousals in slow-wave sleep

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Author(s):
dos Santos Lima, Gustavo Zampier [1, 2, 3] ; Lobao-Soares, Bruno [1] ; Corso, Gilberto [1] ; Belchior, Hindiael [4] ; Lopes, Sergio Roberto [5] ; Prado, Thiago de Lima [6] ; Nascimento, George [7] ; de Franca, Arthur Cavalcanti [8] ; Fontenele-Araujo, John [9] ; Ivanov, Plamen Ch [3, 10, 11]
Total Authors: 10
Affiliation:
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[1] Univ Fed Rio Grande do Norte, Dept Biofis & Farmacol, Natal, RN - Brazil
[2] Univ Fed Rio Grande do Norte, Escola Ciencias & Tecnol, Natal, RN - Brazil
[3] Boston Univ, Keck Lab Network Physiol, Dept Phys, 590 Commonwealth Ave, Boston, MA 02215 - USA
[4] Univ Fed Rio Grande do Norte, Fac Ciencias Saude Trairi, Natal, RN - Brazil
[5] Univ Fed Parana, Dept Fis, Curitiba, Parana - Brazil
[6] Univ Fed Vales Jequitinhonha & Mucuri, Inst Engn Ciencia & Tecnol, Janauba, MG - Brazil
[7] Univ Fed Rio Grande do Norte, Dept Engn Biomed, Natal, RN - Brazil
[8] Univ Fed Rio Grande do Norte, Inst Cerebro, Natal, RN - Brazil
[9] Univ Fed Rio Grande do Norte, Dept Fisiol & Comportamento, Natal, RN - Brazil
[10] Div Sleep Med, Boston, MA 02115 - USA
[11] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 - USA
Total Affiliations: 11
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 9, APR 10 2019.
Web of Science Citations: 0
Abstract

Sleep plays a crucial role in the regulation of body homeostasis and rhythmicity in mammals. Recently, a specific component of the sleep structure has been proposed as part of its homeostatic mechanism, named micro-arousal. Here, we studied the unique progression of the dynamic behavior of cortical and hippocampal local field potentials (LFPs) during slow-wave sleep-related to motor-bursts (micro-arousals) in mice. Our main results comprised: (i) an abrupt drop in hippocampal LFP amplitude preceding micro-arousals which persisted until the end of motor-bursts (we defined as t interval, around 4s) and a similar, but delayed amplitude reduction in cortical (S1/M1) LFP activity occurring at micro-arousal onset; (ii) two abrupt frequency jumps in hippocampal LFP activity: from Theta (6-12 Hz) to Delta (2-4 Hz), also t seconds before the micro-arousal onset, and followed by another frequency jump from Delta to Theta range (5-7 Hz), now occurring at micro-arousal onset; (iii) a pattern of cortico-hippocampal frequency communication precedes micro-arousals: the analysis between hippocampal and cortical LFP fluctuations reveal high coherence during tau interval in a broader frequency band (2-12 Hz), while at a lower frequency band (0.5-2 Hz) the coherence reaches its maximum after the onset of micro-arousals. In conclusion, these novel findings indicate that oscillatory dynamics pattern of cortical and hippocampal LFPs preceding micro-arousals could be part of the regulatory processes in sleep architecture. (AU)

FAPESP's process: 15/23487-8 - Transitions in coupled non-stationary complex systems with minimal perturbation
Grantee:Thiago de Lima Prado
Support Opportunities: Scholarships in Brazil - Post-Doctoral