Cross-tolerance between nitric oxide synthase inhibition and atypical antipsychotics modify nicotinamide-adenine-dinucleotide phosphate-diaphorase activity in mouse lateral striatum

Author(s)

Prieto, Sonia G. ^[1] ; Silva, Joao C. S. ^[2] ; de Lima, Mairon O. ^[2] ; Almeida, Maria C. ^[3] ; Echeverry, Marcela B. ^{[2, 4, 5]}

Affiliation

^[1] Univ Fed ABC, Dept Neurosci & Cognit, Sao Bernardo Do Campo - Brazil

^[2] Univ Fed ABC, Sao Bernardo Do Campo - Brazil

^[3] Univ Fed ABC, Ctr Nat & Human Sci, Sao Bernardo Do Campo - Brazil

^[4] Univ Fed ABC, Ctr Math Computat & Cognit, Rua Arcturus 03, BR-09606070 Sao Bernardo Do Campo - Brazil

^[5] Univ Santander, Sch Med, Neurosci Lab, Bucaramanga - Colombia

• Document type: Journal article
• Source: Behavioural Pharmacology; v. 30, n. 1, p. 67-78, FEB 2019.
• Web of Science Citations: 0

Abstract

Previous research indicates that the subchronic administration of NG-nitro-L-arginine (L-NOARG) produces tolerance to haloperidol-induced catalepsy in Swiss mice. The present study aimed to further investigate whether intermittent subchronic systemic administration of L-NOARG induces tolerance to the cataleptic effects of haloperidol as well as olanzapine or clozapine (Clz) in C57Bl mice after subchronic administration for 5 consecutive days. Striatal FosB protein expression was measured in an attempt to gain further insights into striatal mechanisms in antipsychotic-induced extrapyramidal symptoms side effects. An nicotinamide-adenine-dinucleotide phosphate-diaphorase histochemical reaction was also used to investigate whether tolerance could induce changes in the number of nitric oxide synthase-active neurons. Subchronic administration of all antipsychotics produced catalepsy, but cross-tolerance was observed only between L-NOARG (15 mg/kg, intraperitoneally) and Clz (20 mg/kg, intraperitoneally). This cross-tolerance effect was accompanied by decreased FosB protein expression in the dorsal striatum and the nucleus accumbens shell region, and reduced icotinamide-adenine-dinucleotide phosphate-diaphorase activity in the dorsal and ventral lateral striatum. Overall, these results suggest that interference with the formation of nitric oxide, mainly in the dorsal and ventral lateral-striatal regions, appears to improve the cataleptic effects induced by antipsychotics acting as antagonists of low-affinity dopamine D2 receptor, such as Clz. Copyright (c) 2018 Wolters Kluwer Health, Inc. All rights reserved. (AU)

• FAPESP's process: 15/02991-0 - Involvement of TRPM8 channels in thermoregulation of Wistar rats
• Grantee: Maria Camila Almeida
• Support Opportunities: Regular Research Grants