Cancer-associated thrombosis: the when, how and why

Author(s)

Fernandes, Jr., Caio J. ^[1] ; Morinaga, Luciana T. K. ^[1] ; Alves, Jose L. ^[1] ; Castro, Marcela A. ^[1] ; Calderaro, Daniela ^[1] ; Jardim, Carlos V. P. ^[1] ; Souza, Rogerio ^[1]

Affiliation

^[1] Univ Sao Paulo, Med Sch, Dept Cardiopulmonol, Heart Inst, 44 Av Dr Eneas de Carvalho Aguiar, BR-05403000 Sao Paulo - Brazil

• Document type: Review article
• Source: EUROPEAN RESPIRATORY REVIEW; v. 28, n. 151 MAR 31 2019.
• Web of Science Citations: 3

Abstract

Cancer-associated thrombosis (CAT) is a condition in which relevance has been increasingly recognised both for physicians that deal with venous thromboembolism (VTE) and for oncologists. It is currently estimated that the annual incidence of VTE in patients with cancer is 0.5% compared to 0.1% in the general population. Active cancer accounts for 20% of the overall incidence of VTE. Of note, VTE is the second most prevalent cause of death in cancer, second only to the progression of the disease, and cancer is the most prevalent cause of deaths in VTE patients. Nevertheless, CAT presents several peculiarities that distinguish it from other VTE, both in pathophysiology mechanisms, risk factors and especially in treatment, which need to be considered. CAT data will be reviewed in this review. (AU)

• FAPESP's process: 17/26871-9 - Prognostic markers in patients with acute pulmonary embolism submitted to reperfusion by endovascular methods
• Grantee: Caio Júlio César dos Santos Fernandes
• Support Opportunities: Scholarships abroad - Research