| Full text | |
| Author(s): |
Bruno Fonseca-Santos
[1]
;
Erica Emi Funagoshi
[2]
;
José Ricardo Soares de Oliveira
[3]
;
Luis Vitor Silva do Sacramento
[4]
;
André Gonzaga dos Santos
[5]
;
Gislaine Ricci Leonardi
[6]
;
Marlus Chorilli
[7]
Total Authors: 7
|
| Affiliation: | [1] São Paulo State University. School of Pharmaceutical Sciences. Department of Drugs and Medicines - Brasil
[2] São Paulo State University. School of Pharmaceutical Sciences. Department of Drugs and Medicines - Brasil
[3] São Paulo State University. School of Pharmaceutical Sciences. Department of Natural Products and Toxicology - Brasil
[4] São Paulo State University. School of Pharmaceutical Sciences. Department of Natural Products and Toxicology - Brasil
[5] São Paulo State University. School of Pharmaceutical Sciences. Department of Natural Products and Toxicology - Brasil
[6] University of Campinas. Faculty of Pharmaceuticals Sciences - Brasil
[7] São Paulo State University. School of Pharmaceutical Sciences. Department of Drugs and Medicines - Brasil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Pharmaceutical Sciences; v. 53, n. 3 2017-10-26. |
| Abstract | |
ABSTRACT This study was to develop, characterize, and evaluate the physical-chemical stability, in vitro antioxidant activity and in vitro safety profile of liquid crystalline systems (LCS) and microemulsions (MEs) with and without organic cocoa (OC) extract. LCS stabilized by surfactant polyoxyethylene 20 cetyl ether, containing water and oleic acid were studied. LCS and MEs were characterized using polarized light microscopy, small angle X-ray scattering, rheology and in vitro bioadhesion, and were evaluated for a period of 30 days by visual aspects, centrifuge test, pH value and relative density. PLM and SAXS assays showed the presence of domains of MEs, cubic and hexagonal mesophasephases, varying the proportions of the components of the formulations; where in the addition of the extract did not change rheological behavior of the formulations. All of the formulations were stable in the period analyzed and presented higher bioadhesive strength. In vitro antioxidant activity suggests that LCS and MEs presented a high capacity to maintain the antioxidant activity of OC extract. The results showed that the incorporation of OC in LCS improved the safety profile, according to cytotoxicity assays of systems may be a promising platform to OC extract for topical application for the potential treatment of skin disorders. (AU) | |
| FAPESP's process: | 10/17723-7 - Evaluation of the potential of nanostructured systems for incorporation of organic cocoa: study of the physico-chemical stability and antioxidant activity |
| Grantee: | Erica Emi Funagoshi |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |