| Full text | |
| Author(s): |
Meneghini, A. C.
[1]
;
Koenigkam-Santos, M.
[2]
;
Pereira, M. C.
[3]
;
Tonidandel, P. R.
[3]
;
Terra-Filho, J.
[2]
;
Cunha, F. Q.
[4]
;
de Menezes, M. B.
[2]
;
Vianna, E. O.
[2]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med Social, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Ribeirao Preto, SP - Brazil
[3] Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, Campinas, SP - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Medical and Biological Research; v. 52, n. 5 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Special attention has emerged towards biomass smoke-induced chronic obstructive pulmonary disease (COPD), providing new knowledge for prevention and therapeutic approach of non-smoker COPD patients. However, the understanding of biomass smoke COPD is still limited and somewhat controversial. The aim of the present study was to compare COPD exclusively caused by tobacco smoking with COPD exclusively caused by environmental or occupational exposures. For this cross-sectional study, COPD patients were recruited from outpatient clinics and formed two groups: non-smoker COPD group (n=16) with exposure to biomass smoke who did not smoke cigarette and tobacco smoker COPD group (n=15) with people who did not report biomass smoke exposure. Subjects underwent pulmonary function tests, thoracic high-resolution computed tomography, 6-min walk test, and sputum induction. The non-smoker COPD group had biomass smoke exposure of 133.3±86 hour-years. The tobacco COPD group smoked 48.5±27.4 pack-years. Women were 62.5 and 66.7%, respectively, of non-smokers and smokers. The non-smoker COPD group showed higher prevalence of dyspnea, lower arterial oxygen tension (PaO2), and lower arterial oxygen saturation (SaO2%) with similar spirometry results, lung volumes, and diffusion capacity. Regarding inflammatory biomarkers, differences were detected in sputum number of lymphomononuclear cells and in sputum concentrations of interleukin (IL)-6 and IL-8 with higher values in the smoker group. Emphysema was more prevalent in the tobacco smoker group, which also showed higher relative bronchial wall thickness and lower lung density by quantitative analysis. Biomass smoke induced more hypoxemia compared to tobacco in COPD patients with similar severity. (AU) | |
| FAPESP's process: | 17/21035-8 - Work-related allergic sensitization and asthma: longitudinal studies for characterization and prevention |
| Grantee: | Elcio dos Santos Oliveira Vianna |
| Support Opportunities: | Research Projects - Thematic Grants |