Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Carbon dioxide-catalyzed peroxynitrite reactivity - The resilience of the radical mechanism after two decades of research

Full text
Author(s):
Augusto, Ohara [1] ; Goldstein, Sara [2] ; Hurst, James K. [3] ; Lind, Johan [4] ; Lymar, V, Sergei ; Merenyi, Gabor [4] ; Radi, Rafael [5, 6]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-5508000 Sao Paulo - Brazil
[2] Hebrew Univ Jerusalem, Chem Inst, IL-91904 Jerusalem - Israel
[3] Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 - USA
[4] Royal Inst Technol, Sch Chem, S-10044 Stockholm - Sweden
[5] Univ Republica, Ctr Free Rad & Biomed Res, Fac Med, Montevideo 11800 - Uruguay
[6] Univ Republica, Dept Bioquim, Fac Med, Montevideo 11800 - Uruguay
Total Affiliations: 6
Document type: Review article
Source: Free Radical Biology and Medicine; v. 135, p. 210-215, MAY 1 2019.
Web of Science Citations: 1
Abstract

Peroxynitrite, ONOO-, formed in tissues that are simultaneously generating NO center dot and O-2(center dot-), is widely regarded as a major contributor to oxidative stress. Many of the reactions involved are catalyzed by CO2 via formation of an unstable adduct, ONOOC(O)O-, that undergoes O-O bond homolysis to produce NO2 center dot and CO3 center dot- radicals, whose yields are equal at about 0.33 with respect to the ONOO- reactant. Since its inception two decades ago, this radical-based mechanism has been frequently but unsuccessfully challenged. The most recent among these {[}Serrano-Luginbuehl et al. Chem. Res. Toxicol. 31: 721-730; 2018] claims that ONOOC(O)O- is stable, predicts a yield of NO2 center dot/CO3 center dot- of less than 0.01 under physiological conditions and, contrary to widely accepted viewpoints, suggests that radical generation is inconsequential to peroxynitrite-induced oxidative damage. Here we review the experimental and theoretical evidence that support the radical model and show this recently proposed alternative mechanism to be incorrect. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC