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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Macroporous hydrogels based on carbohydrates monomethacrylates and dimethacrylates: singular properties from carbohydrate-based crosslinkers

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Perin, Giovanni Bortoloni [1] ; Fonseca, Lucas Polo [1] ; Felisberti, Maria Isabel [1]
Total Authors: 3
[1] Univ Estadual Campinas, Inst Chem, Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY; v. 94, n. 6, p. 1913-1924, JUN 2019.
Web of Science Citations: 1

BACKGROUND Readily available feedstock and biocompatibility make carbohydrate-based hydrogels promising materials for biomedical applications. However, carbohydrate-based crosslinkers are rather underexplored when compared with crosslinkers derived from fossil resources. In this study, novel fully bio-based hydrogels derived from enzymatically produced d-fructose and d-glucose methacrylate monomers were synthesized with different amounts of d-fructose dimethacrylate crosslinker. RESULTS The use of a carbohydrate-based crosslinker endows hydrogels with high swelling coefficients, up to 2400%, and superior mechanical resistance (compressive modulus up to 9.5 kPa with a maximum stress up to 50 kPa) compared with conventional crosslinkers based on fossil resources. Hydrogels shape and crosslinking density influences hydrogel morphology, swelling behavior and mechanical resistance. Moreover, hydrogels presented cell viability, biodegradability and hydrolysis-resistance over a wide range of pH. CONCLUSION The use of a highly hydrophilic crosslinker based on carbohydrate for hydrogels synthesis enables the use of high crosslinker concentration, which improves mechanical properties, however with minor loss of the water swelling capacity, compared with conventional fossil-based crosslinkers. This is an important advantage over conventional crosslinkers based on fossil resources. Moreover, slab hydrogels hold higher stress under compression-decompression cycles, and present higher resistance to hydrolysis in basic medium due to the thicker pore walls than cylindrical ones. (c) 2019 Society of Chemical Industry (AU)

FAPESP's process: 10/17804-7 - Polymeric composites
Grantee:Maria Isabel Felisberti
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/14232-3 - Hydrogels based on polymethacrylates of glucose and fructose
Grantee:Giovanni Bortoloni Perin
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
Grantee:Watson Loh
Support Opportunities: Research Projects - Thematic Grants