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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Frontal-subcortical behaviors during Alzheimer's disease in individuals with Down syndrome

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Author(s):
Fonseca, Luciana Mascarenhas [1, 2] ; Mattar, Guilherme Prado [2] ; Haddad, Glenda Guerra [2] ; Goncalves, Aline Souza [3] ; Constantino Miguel, Andre de Queiroz [4] ; Guilhoto, Laura Maria [5, 6] ; Zaman, Shahid [1] ; Holland, Anthony J. [1] ; de Campos Bottino, Cassio Machado [2] ; Hoexter, Marcelo Queiroz [7]
Total Authors: 10
Affiliation:
[1] Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge - England
[2] Univ Sao Paulo, Sch Med, FMUSP, Old Age Res Grp, PROTER, Dept & Inst Psychiat, Sao Paulo - Brazil
[3] Univ Sao Paulo, FMUSP, Sch Med, Lab Neurosci, LIM27 Dept & Inst Psychiat, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo - Brazil
[6] Assoc Parents & Friends Individuals Intellectual, Sao Paulo - Brazil
[7] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, FMUSP, Obsess Compuls Spectrum Disorders Program, PROTOC, Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Source: NEUROBIOLOGY OF AGING; v. 78, p. 186-194, JUN 2019.
Web of Science Citations: 0
Abstract

There is evidence that frontal-subcortical circuits play an important role in the initial presentation of dementia in Down syndrome (DS), including changes in behavior, a decline in working memory and executive dysfunction. We evaluated 92 individuals with DS (>= 30 years of age), divided into 3 groups by diagnosis-stable cognition, prodromal dementia, and Alzheimer's disease. Each individual was evaluated with an executive protocol developed for people with intellectual disabilities and was rated for behaviors related to frontal lobe dysfunction (disinhibition, executive dysfunction, and apathy) by an informant using the Frontal Systems Behavior Scale. Informant-reported behaviors related to frontal lobe dysfunction were found to correlate negatively with executive function performance. Disinhibition and executive dysfunction were associated with the clinical stage of dementia. The odds of having Alzheimer's disease increased in parallel with increases in the domain and total Frontal Systems Behavior Scale scores (p <= 0.5). Disinhibition, executive dysfunction and apathy should be taken into consideration during the clinical evaluation of adults with DS, and future studies should consider the intersection of neuropathology, brain connectivity, and behavior. (C) 2019 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/11571-9 - Risk factors for dementia and cognitive decline in adults with Down Syndrome and the CAMDEX-DS validation
Grantee:Luciana Mascarenhas Fonseca
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/22123-5 - Proposal of research internship on dementia, Down syndrome and neuroimage at Department of Psychiatry of University of Cambridge
Grantee:Luciana Mascarenhas Fonseca
Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)