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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Understanding the Metabolic Profile of Macrophages During the Regenerative Process in Zebrafish

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Paredes, Lais Cavalieri [1] ; Saraiva Camara, Niels Olsen [2, 3, 4] ; Braga, Tarcio Teodoro [1]
Total Authors: 3
[1] Univ Fed Parana, Dept Pathol, Curitiba, Parana - Brazil
[2] Univ Fed Sao Paulo, Nephrol Div, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Renal Pathophysiol Lab, Fac Med, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Review article
Source: FRONTIERS IN PHYSIOLOGY; v. 10, MAY 24 2019.
Web of Science Citations: 0

In contrast to mammals, lower vertebrates, including zebrafish (Danio rerio), have the ability to regenerate damaged or lost tissues, such as the caudal fin, which makes them an ideal model for tissue and organ regeneration studies. Since several diseases involve the process of transition between fibrosis and tissue regeneration, it is necessary to attain a better understanding of these processes. It is known that the cells of the immune system, especially macrophages, play essential roles in regeneration by participating in the removal of cellular debris, release of pro- and anti-inflammatory factors, remodeling of components of the extracellular matrix and alteration of oxidative patterns during proliferation and angiogenesis. Immune cells undergo phenotypical and functional alterations throughout the healing process due to growth factors and cytokines that are produced in the tissue microenvironment. However, some aspects of the molecular mechanisms through which macrophages orchestrate the formation and regeneration of the blastema remain unclear. In the present review, we outline how macrophages orchestrate the regenerative process in zebrafish and give special attention to the redox balance in the context of tail regeneration. (AU)

FAPESP's process: 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology
Grantee:Niels Olsen Saraiva Câmara
Support type: Research Projects - Thematic Grants