Mullite cytotoxicity and cell adhesion studies

Author(s)

Fernandes, Leandro ^[1] ; de Carvalho, Renata Aquino ^[2] ; Amaral, Andre Capaldo ^[2] ; Pecoraro, Edison ^[3] ; Salomao, Rafael ^[1] ; Trouatti, Eliane ^[2]

Affiliation

^[1] Univ Sao Paulo, Sao Carlos Sch Engn, Mat Engn Dept, Ave Trabalhador Sao Carlense 400, BR-13566590 Sao Carlos, SP - Brazil

^[2] Univ Araraquara UNIARA, Rua Carlos Gomes 1217, BR-14801340 Araraquara, SP - Brazil

^[3] Sao Paulo State Univ, Inst Chem, UNESP, BR-14800060 Araraquara, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T; v. 8, n. 3, p. 2565-2572, MAY-JUN 2019.
• Web of Science Citations: 0

Abstract

Mullite is a low cost ceramic material based on aluminous silicate and synthesized via solid state reaction. Mullite displays potential properties for application in the biomedical field, specially its high mechanical strength, however it is poorly characterized with respect to its specific cytotoxicity and capability to allow the cell adhesion to its surface. Here, mullite was prepared by sintering the mixture of Al2O3 and SiO2 at 1500 degrees C and characterized. Its elastic modulus was 135 GPa and its flexural strength, 109 MPa. The study of the viability of GM07492 human cells in presence of mullite revealed the proliferation and adhesion of the cells on its surface, which is an indication of biocompatibility. Its good mechanical properties and cytocompatibility suggested that mullite can be used as an alternative material for biomedical applications and dentistry. (C) 2019 The Authors. Published by Elsevier B.V. (AU)

• FAPESP's process: 10/19274-5 - Novel methodology for hydrotalcite (Mg6Al2(OH)16CO3.4H2O) synthesis from aqueous suspensions of magnesium oxide (MgO) and aluminum hydroxide (Al(OH)3) and its application in porous ceramics for high temperature thermal insulation
• Grantee: Rafael Salomão
• Support Opportunities: Research Grants - Young Investigators Grants