Antidiabetic, cytotoxic and antioxidant activities of oil extracted from Acrocomia aculeata pulp

Author(s)

da Silva, Perla V. B. ^[1] ; Ramiro, Marianne M. ^[1] ; Iriguchi, Edna K. K. ^[1] ; Correa, William A. ^[1] ; Lowe, Jennifer ^[2] ; Cardoso, Claudia A. L. ^[3] ; Arena, Arielle C. ^[4] ; Kassuya, Candida A. L. ^[1] ; Muzzi, Rozanna M. ^[1]

Affiliation

^[1] Fed Univ Grande Dourados, Dourados - Brazil

^[2] Univ Fed Rio de Janeiro, Rio De Janeiro - Brazil

^[3] Mato Grosso do Sul State Univ, Dourados - Brazil

^[4] Sao Paulo State Univ UNESP, Inst Biosci Botucatu, Sao Paulo - Brazil

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. 33, n. 16, p. 2413-2416, AUG 18 2019.
• Web of Science Citations: 5

Abstract

This study evaluated the hypoglycemic effect of the oil extracted from the Acrocomia aculeata pulp (OPAC) in normoglycemic rats and streptozotocin (STZ), fructose-induced diabetic rat models and its in vitro antioxidant and cytotoxic potential. OPAC (3, 30 or 300 mg/kg, v.o.) significantly decreased (p < 0.05) the high glucose levels induced by a high fructose-diet in rats. Persistent treatment with OPAC for 24 days also reduced the high plasmatic glucose induced by STZ. In normoglycemic animals, OPAC significantly decreased glucose levels. While A. aculeata oil exhibited good in vitro antioxidant activity, no sign of cytotoxicity was observed in LLC-PK1 cells (5-500 mu g/mL). OPAC has antidiabetic and antioxidant activities without causing in vitro cytotoxicity. {[}GRAPHICS] . (AU)

• FAPESP's process: 13/01802-3 - Evaluation of the effects of oil extracted from Acrocomia aculeata on reproductive toxicity induced by cyclophosphamide in male rats
• Grantee: Arielle Cristina Arena
• Support Opportunities: Regular Research Grants