The use of Z-scan technique for determination of biochemical parameters in children with solid tumors or leukemias supplemented or not with selenium

Author(s)

Alves, S. ^[1] ; Sonego, D. R. N. ^[1] ; Fudimura, K. A. ^[1] ; Hallack, M. L. ^[2] ; Azzalis, L. A. ^[1] ; Junqueira, V. B. C. ^[1] ; Rocha, K. C. ^[2] ; Fonseca, R. L. A. ^[3] ; Figueiredo, F. W. S. ^[2] ; Fonseca, F. L. A. ^{[1, 2]}

Affiliation

^[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Rua Prof Arthur Riedel 275, BR-09972270 Diadema, SP - Brazil

^[2] Fac Med ABC, Lab Anal Clin, Av Principe Gales 821, BR-09060650 Santo Andre, SP - Brazil

^[3] Hosp Sirio Libanes, Serv Pediat, Rua Arma Jafet 115, BR-04514102 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Photodiagnosis and Photodynamic Therapy; v. 26, p. 36-42, JUN 2019.
• Web of Science Citations: 1

Abstract

Cancer is a disease that effects cell metabolism causing an imbalance in the health of the patient. On the other hand, malnutrition, presented by oncological patients, is caused by both the disease and its treatment. Some serum biochemical parameters cannot be determined by the traditional method of laboratory blood analysis (spectrophotometry). Among the various techniques that could be used for blood biochemical analysis, we opted for the Z-scan technique, due to its sensitivity to the reading of blood components. Our objective in this work was to compare the data obtained by the Z-scan technique and the spectrophotometry of the serological samples of children with solid tumors and leukemia under treatment, receiving or not selenium supplementation in a randomized, double-blind clinical trial. The biochemical parameters were read based on blood. These blood sampling made at different stages of chemotherapy and selenium supplementation. At each of these stages, the cholesterol, glucose and triglycerides parameters were read using the Z-scan and spectrophotometry techniques. We observed that selenium helps in balancing the health of these patients, and corroborates with our hypothesis that the Z-scan technique may be an alternative for the determination of biochemical parameters. (AU)

• FAPESP's process: 12/13871-7 - Study of the effects of selenium supplementation in children with leukemia and solid tumors by Z scan technique
• Grantee: Sarah Isabel Pinto Monteiro Do Nascimento Alves
• Support Opportunities: Regular Research Grants