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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology

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Author(s):
Sasahara, Tais H. C. [1] ; Machado, Marcia R. F. [2]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, FMVZ, Dept Cirurgia, Cidade Univ, Ave Prof Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
[2] Univ Estadual Paulista Julio de Mesquita Filho Un, FCAV, Campus Jaboticabal, BR-14884900 Jaboticabal, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 39, n. 5, p. 364-370, MAY 2019.
Web of Science Citations: 0
Abstract

ABSTRACT: Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle. (AU)