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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An Ancient Lineage of Highly Divergent Parvoviruses Infects both Vertebrate and Invertebrate Hosts

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Author(s):
Penzes, Judit J. [1, 2] ; de Souza, William Marciel [3] ; Agbandje-McKenna, Mavis [1, 2] ; Gifford, Robert J. [4]
Total Authors: 4
Affiliation:
[1] Univ Florida, McKnight Brain Inst, 1149 Newell Dr, Gainesville, FL 32610 - USA
[2] Univ Florida, Dept Biochem & Mol Biol, 1149 Newell Dr, Gainesville, FL 32610 - USA
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Virol Res Ctr, Ribeirao Preto - Brazil
[4] Univ Glasgow, Ctr Virus Res, Med Res Council, 464 Bearsden Rd, Glasgow G61 1QH, Lanark - Scotland
Total Affiliations: 4
Document type: Journal article
Source: Viruses-Basel; v. 11, n. 6 JUN 2019.
Web of Science Citations: 0
Abstract

Chapparvoviruses (ChPVs) comprise a divergent, recently identified group of parvoviruses (family Parvoviridae), associated with nephropathy in immunocompromised laboratory mice and with prevalence in deep sequencing results of livestock showing diarrhea. Here, we investigate the biological and evolutionary characteristics of ChPVs via comparative in silico analyses, incorporating sequences derived from endogenous parvoviral elements (EPVs) as well as exogenous parvoviruses. We show that ChPVs are an ancient lineage within the Parvoviridae, clustering separately from members of both currently established subfamilies. Consistent with this, they exhibit a number of characteristic features, including several putative auxiliary protein-encoding genes, and capsid proteins with no sequence-level homology to those of other parvoviruses. Homology modeling indicates the absence of a beta -A strand, normally part of the luminal side of the parvoviral capsid protein core. Our findings demonstrate that the ChPV lineage infects an exceptionally broad range of host species, including both vertebrates and invertebrates. Furthermore, we observe that ChPVs found in fish are more closely related to those from invertebrates than they are to those of amniote vertebrates. This suggests that transmission between distantly related host species may have occurred in the past and that the Parvoviridae family can no longer be divided based on host affiliation. (AU)

FAPESP's process: 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing
Grantee:William Marciel de Souza
Support Opportunities: Scholarships in Brazil - Post-Doctoral