Short-term resistance training with instability reduces impairment in V wave and H reflex in individuals with Parkinson's disease

Author(s)

Silva-Batista, Carla ^{[1, 2]} ; de Oliveira Lira, Jumes Leopoldino ^[1] ; David, Fabian J. ^[3] ; Corcos, Daniel M. ^{[3, 4]} ; Tavares Mattos, Eugenia Casella ^[1] ; Coelho, Daniel Boari ^{[5, 6]} ; de Lima-Pardini, Andrea C. ^{[6, 2]} ; Torriani-Pasin, Camila ^[7] ; de Freitas, Tatiana Beline ^[7] ; Ugrinowitsch, Carlos ^[2]

Affiliation

^[1] Univ Sao Paulo, Sch Arts Sci & Humanities, Exercise Neurosci Res Grp, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Adaptat Strength Training, Sao Paulo, SP - Brazil

^[3] Northwestern Univ, Dept Phys Therapy & Human Movement Sci, Chicago, IL 60611 - USA

^[4] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 - USA

^[5] Fed Univ ABC, Biomed Engn, Sao Bernardo Do Campo, SP - Brazil

^[6] Fed Univ ABC, Dept Neurosci, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Sch Phys Educ & Sports, Lab Motor Behav, Dept Pedag Human Body, Sao Paulo - Brazil

• Document type: Journal article
• Source: Journal of Applied Physiology; v. 127, n. 1, p. 89-97, JUL 2019.
• Web of Science Citations: 0

Abstract

This study had two objectives: 1) to compare the effects of 3 wk of resistance training (RT) and resistance training with instability (RTI) on evoked reflex responses at rest and during maximal voluntary isometric contraction (MVIC) of individuals with Parkinson's disease (PD) and 2) to determine the effectiveness of RT and RTI in moving values of evoked reflex responses of individuals with PD toward values of age-matched healthy control subjects (HCs) (z-score analysis). Ten individuals in the RT group and 10 in the RTI group performed resistance exercises twice a week for 3 wk, but only the RTI group included unstable devices. The HC group (n = 10) were assessed at pretest only. Evoked reflex responses at rest (H reflex and M wave) and during MVIC {[}supramaximal M-wave amplitude (M-sup) and supramaximal V-wave amplitude (V-sup)] of the plantar flexors were assessed before and after the experimental protocol. From pretraining to posttraining, only RTI increased ratio of maximal H-reflex amplitude to maximal M-wave amplitude at rest (H-max/M-max), M-sup, V-sup/M-sup, and peak torque of the plantar flexors (P < 0.05). At posttraining, RTI was more effective than RT in increasing resting H-max and V-sup and in moving these values to those observed in HCs (P < 0.05). We conclude that short-term RTI is more effective than short-term RT in modulating H-reflex excitability and in increasing efferent neural drive, approaching average values of HCs. Thus short-term RTI may cause positive changes at the spinal and supraspinal levels in individuals with PD. NEW \& NOTEWORTHY Maximal H-reflex amplitude (H-max) at rest and efferent neural drive {[}i.e., supramaximal V-wave amplitude (V-sup)] to skeletal muscles during maximal contraction are impaired in individuals with Parkinson's disease. Short-term resistance training with instability was more effective than short-term resistance training alone in increasing H-max and V-sup of individuals with Parkinson's disease, reaching the average values of healthy control subjects. (AU)

• FAPESP's process: 18/16909-1 - Effects of resistance training with instability on clinical outcomes, spinal mechanisms, and brain metrics in individuals with freezing of gait in Parkinson's disease
• Grantee: Carla da Silva Batista
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 16/13115-9 - Effects of resistance training with instability on clinical outcomes, spinal mechanisms, and brain metrics in individuals with freezing of gait in Parkinson's disease
• Grantee: Carla da Silva Batista
• Support Opportunities: Scholarships in Brazil - Post-Doctoral