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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats

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Author(s):
Colli, Lucas Giglio [1] ; Belardin, Larissa Berloffa [2] ; Echem, Cinthya [1] ; Akamine, Eliana Hiromi [1] ; Antoniassi, Mariana Pereira [2] ; Andretta, Rhayza Roberta [2] ; Mathias, Lucas Solla [3] ; de Paula Rodrigues, Stephen Fernandes [1] ; Bertolla, Ricardo Pimenta [2] ; Catelli de Carvalho, Maria Helena [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, ICB, Hypertens Sect, Dept Pharmacol, Div Vasc Biol, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Div Urol, Dept Surg, Sao Paulo - Brazil
[3] Univ Estadual Paulista UNESP, Botucatu Med Univ, Dept Internal Med, Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 9, JUL 30 2019.
Web of Science Citations: 0
Abstract

Arterial hypertension is a cardiovascular disease that leads to important systemic alterations and drastically impairs normal organ function over time. Hypertension affects around 700 million men of reproductive age and hypertensive men present increased risk for reproductive disorders, such as erectile dysfunction. However, the link between arterial hypertension and male reproductive disorders is associative at best. Moreover, many studies have reported associations between decreased male fertility and/or semen quality and alterations to general male health. In this study we aim to investigate the effect of systemic high blood pressure in sperm quality, sperm functional characteristics and testicular physiology in a rat model. Hypertensive rats presented altered testicular morphology mainly vascular alterations and impaired testicular vasomotion. Hypertensive rats also presented decrease in sperm concentration, DNA integrity and increased percentages of sperm with dysfunctional mitochondria, intracellular superoxide anion activity and abnormal morphology. This study provides mechanistic insights by which arterial hypertension affects the testes, evidencing the testes as another target organ for hypertension as well as its impact on sperm quality. (AU)

FAPESP's process: 16/05487-3 - Epididymal regulation of fertility in men.
Grantee:Larissa Berloffa Belardin
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/04281-0 - Therapeutical efficacy of gold nanoparticles to multiform glioblastoma or septic encephalophaty in mice
Grantee:Stephen Fernandes de Paula Rodrigues
Support Opportunities: Scholarships in Brazil - Young Researchers