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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Adjuvanted leptospiral vaccines: Challenges and future development of new leptospirosis vaccines

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Author(s):
Teixeira, Aline F. [1] ; Fernandes, V, Luis G. ; Cavenague, Maria F. [2, 3] ; Takahashi, Maria B. [2, 3] ; Santos, Jademilson C. [2] ; Passalia, Felipe J. [2, 3] ; Daroz, Brenda B. [2, 3] ; Kochi, Leandro T. [2, 3] ; Vieira, Monica L. [2] ; Nascimento, Ana L. T. O. [2]
Total Authors: 10
Affiliation:
[1] Inst Butantan, Ctr Biotecnol, Lab Especial Desenvolvimento Vacinas, Ave Vital Brazil 1500, BR-05503900 Sao Paulo, SP - Brazil
[2] Fernandes, Luis G., V, Inst Butantan, Ctr Biotecnol, Lab Especial Desenvolvimento Vacinas, Ave Vital Brazil 1500, BR-05503900 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Ciencias Biomed, Programa Posgrad Interunidades Biotecniol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: Vaccine; v. 37, n. 30, p. 3961-3973, JUL 9 2019.
Web of Science Citations: 1
Abstract

Leptospirosis is a neglected infectious disease of global importance. Vaccination is the most viable strategy for the control of leptospirosis, but in spite of efforts for the development of an effective vaccine against the disease, few advances have been made, and to date, bacterin is the only option for prevention of leptospirosis. Bacterins are formulations based on inactivated leptospires that present a series of drawbacks, such as serovar-dependence and short-term immunity. Therefore, bacterins are not widely used in humans, and only Cuba, France and China have these vaccines licensed for at-risk populations. The development of recombinant DNA technology emerges as an alternative to solve the problem. Recombinant protein-based vaccines or DNA vaccines seem to be an attractive strategy, but the use of adjuvants is critical for achievement of a protective immune response. Adjuvants are capable of enhancing and/or modulating immune responses by exposing antigens to antigen-presenting cells. In the last years, several components have been tested as adjuvants, such as aluminum salts, oil based-emulsion adjuvants, bacteria-derived components and liposomes. This review highlights the use of adjuvants in the multiple vaccine approaches that have been used for leptospirosis and their most important immunological aspects. Immune response data generated by these strategies can contribute to the understanding of the immune mechanisms involved in protection against leptospirosis, and consequently, the development of effective vaccines against this disease. This is the first review on leptospiral vaccines focusing on adjuvant aspects. (C) 2019 Published by Elsevier Ltd. (AU)

FAPESP's process: 17/26223-7 - Evaluation of functional role of Leptospira interrogans surface proteins as endothelial and epithelial cells receptors of the host
Grantee:Maria Beatriz Takahashi
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 17/01411-5 - Cloning, expression and characterization of HtrA proteins of Leptospira interrogans
Grantee:Brenda Daroz
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/50981-0 - Search for surface proteins among the genome sequences of Leptospira interrogans: functional and immunological characterization to understanding mechanisms involved in the bacterial pathogenesis
Grantee:Ana Lucia Tabet Oller Do Nascimento
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/06731-8 - Development of new strategies for genetic manipulation in Leptospira spp.: antisense RNA and CRISPR/Cas9
Grantee:Luis Guilherme Virgílio Fernandes
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/01102-2 - Biochemical and immunological evaluation of hypothetical surface proteins of Leptospira interrogans
Grantee:Felipe José Passalia
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 17/25167-6 - Structural characterization of surface proteins of Leptospira interrogans and thermodynamics of the interaction with host-components
Grantee:Jademilson Celestino dos Santos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/00236-5 - Platelets at the interface of immunity, inflammation and hemostasis modulation in leptospirosis
Grantee:Mônica Larucci Vieira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 16/11541-0 - "Evaluation of immunoprotective potential of CD4+ T-cell epitopes identified in proteins of Leptospira interrogans"
Grantee:Aline Rodrigues Florêncio Teixeira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/01384-5 - Evaluation of the functional role of two Leptospira interrogans proteins in the adhesion process of the pathogen to the host
Grantee:Leandro Toshio Kochi
Support type: Scholarships in Brazil - Master