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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Renal developmental disturbances and their long-term consequences in female pups from vitamin D-deficient mothers: involved mechanisms

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Author(s):
Almeida, L. F. [1] ; Francescato, H. D. C. [1] ; Silva, R. S. [2] ; Silva, C. G. A. [1] ; Antunes-Rodrigues, J. [1] ; de Paula, F. J. A. [3] ; Coimbra, T. M. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Internal Med, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE; v. 10, n. 4, p. 497-501, AUG 2019.
Web of Science Citations: 2
Abstract

The mechanisms involved in kidney disturbances during development, induced by vitamin D-3 deficiency in female rats, that persist into adulthood were evaluated in this study. Female offspring from mothers fed normal (control group, n=8) or vitamin D-deficient (Vit.D-, n=10) diets were used. Three-month-old rats had their systolic blood pressure (SBP) measured and their blood and urine sampled to quantify vitamin D-3 (Vit.D-3), creatinine, Na+, Ca+2 and angiotensin II (ANGII) levels. The kidneys were then removed for nitric oxide (NO) quantification and immunohistochemical studies. Vit.D- pups showed higher SBP and plasma ANGII levels in adulthood (P<0.05) as well as decreased urine osmolality associated with increases in urinary volume (P<0.05). Decreased expression of JG12 (renal cortex and glomeruli) and synaptopodin (glomeruli) as well as reduced renal NO was also observed (P<0.05). These findings showed that renal disturbances in development in pups from Vit.D- mothers observed in adulthood may be related to the development of angiogenesis, NO and ANGII alterations. (AU)

FAPESP's process: 17/07118-8 - Influence of vitamin D on renal development in rats
Grantee:Lucas Ferreira de Almeida
Support Opportunities: Scholarships in Brazil - Doctorate